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首页> 外文期刊>Asian Journal of Andrology >Effect of lead chloride on spermatogenesis and sperm parameters in mice
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Effect of lead chloride on spermatogenesis and sperm parameters in mice

机译：氯化铅对小鼠精子发生和精子参数的影响

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Aim: To evaluate the effect of acute lead chloride exposure on testis and sperm parameters in mice. Methods: PbCl_2, 74 mg/kg, was daily administered to sexually mature male mice for 3 days and the effects on the testicular histology and ultrastructure as well as the motility and density of spermatozoa in cauda epididymis were observed. An additional group of mice were treated for 1-3 days and were allowed to recover for 32 days to determine the reversibility of lead-induced changes. Results: The testicular weight, seminiferous tubular diameter and sperm counts were significantly decreased following 3 days of PbCl_2 treatment, but were unaffected by shorter-term exposures. The changes caused by lead are mostly reversible. Conclusion: Acute lead chloride exposure injures the fertility parameters of male mice and the effects are partially reversible.
机译：目的：评估急性氯化铅暴露对小鼠睾丸和精子参数的影响。方法：每天向性成熟雄性小鼠施用74 mg / kg的PbCl_2，持续3天，观察其对附睾睾丸组织学和超微结构以及精子活力和密度的影响。另一组小鼠治疗1-3天，并使其恢复32天，以确定铅诱导的变化的可逆性。结果：PbCl_2治疗3天后，睾丸重量，生精管直径和精子计数显着降低，但不受短期暴露的影响。铅引起的变化大部分是可逆的。结论：急性氯化铅暴露会损害雄性小鼠的生育能力，其作用是部分可逆的。

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