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首页> 外文期刊>Acta astronautica >Prediction of trabecular bone qualitative properties using scanning quantitative ultrasound
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Prediction of trabecular bone qualitative properties using scanning quantitative ultrasound

机译：使用扫描定量超声预测小梁骨的定性性质

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Microgravity induced bone loss represents a critical health problem in astronauts, particularly occurred in weight-supporting skeleton, which leads to osteopenia and increase of fracture risk. Lack of suitable evaluation modality makes it difficult for monitoring skeletal status in long term space mission and increases potential risk of complication. Such disuse osteopenia and osteoporosis compromise trabecular bone density, and architectural and mechanical properties. While X-ray based imaging would not be practical in space, quantitative ultrasound may provide advantages to characterize bone density and strength through wave propagation in complex trabecular structure. This study used a scanning confocal acoustic diagnostic and navigation system (SCAN) to evaluate trabecular bone quality in 60 cubic trabecular samples harvested from adult sheep. Ultrasound image based SCAN measurements in structural and strength properties were validated by μCT and compressive mechanical testing. This result indicated a moderately strong negative correlations observed between broadband ultrasonic attenuation (BUA) and μCT-determined bone volume fraction (BV/TV, R~2=0.53). Strong correlations were observed between ultrasound velocity (UV) and bone's mechanical strength and structural parameters, i.e., bulk Young's modulus (R~2=0.67) and BV/TV (R~2=0.85). The predictions for bone density and mechanical strength were significantly improved by using a linear combination of both BUA and UV, yielding R~2=0.92 for BV/TV and R~2=0.71 for bulk Young's modulus. These results imply that quantitative ultrasound can characterize trabecular structural and mechanical properties through measurements of particular ultrasound parameters, and potentially provide an excellent estimation for bone's structural integrity.
机译：微重力引起的骨质流失代表了宇航员的重要健康问题，尤其是在支撑体重的骨骼中，这会导致骨质减少和骨折风险增加。缺乏合适的评估方式使长期太空任务中监测骨骼状态变得困难，并增加了潜在的并发症风险。这种废用性骨质减少和骨质疏松损害了小梁的骨密度以及建筑和机械性能。虽然基于X射线的成像在空间中不可行，但定量超声可能会提供优势，可以通过复杂的小梁结构中的波传播来表征骨密度和强度。这项研究使用扫描共聚焦声学诊断和导航系统（SCAN）来评估从成年绵羊收获的60立方小梁样品中的小梁骨质量。通过μCT和压缩机械测试验证了基于超声图像的结构和强度特性的SCAN测量结果。该结果表明在宽带超声衰减（BUA）和μCT确定的骨体积分数（BV / TV，R〜2 = 0.53）之间观察到中等程度的负相关。观察到超声速度（UV）与骨骼的机械强度和结构参数（即，体积杨氏模量（R〜2 = 0.67）和BV / TV（R〜2 = 0.85））之间存在很强的相关性。通过使用BUA和UV的线性组合，对骨密度和机械强度的预测得到了显着改善，BV / TV的R〜2 = 0.92，体积杨氏模量的R〜2 = 0.71。这些结果表明，定量超声可以通过特定超声参数的测量来表征小梁的结构和机械特性，并有可能为骨骼的结构完整性提供出色的估计。

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