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首页> 外文期刊>Acta astronautica >Effects of short-term -12° head-down tilt on cognitive performance
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Effects of short-term -12° head-down tilt on cognitive performance

机译：短期-12°下降倾斜对认知性能的影响

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Background: Microgravity-induced fluid shifts and the resulting changes in cerebral hemodynamics may be linked to cognitive performance alterations in spaceflight. Head-down tilt (HDT) bed rest serves as a well-validated spaceflight analog for microgravity-induced cephalic fluid shifts. This study examined the effects of short-term (t 4 h) changes in body position (supine or -12 degrees HDT) relative to a 45 degrees upright position on cognitive performance.Methods: In this within-subject cross-over study, ten male subjects without significant medical comorbidities (mean +/- standard deviation [SD] age: 34 years +/- 3, weight: 81 kg +/- 11, height: 1.77 m +/- 0.06, body mass index: 26 kg/m(2) +/- 3) performed the Cognition test battery on an iPad at baseline (45 degrees upright), after 1, 2, 3, and 4 h in the -12 degrees HDT or supine position, and after 30-minute recovery in 45 degrees upright position. The order of conditions ( -12 degrees HDT or supine) was randomized, with 1 week washout between test days.Results: Mixed model analyses of z-transformed Cognition test scores indicate a small (0.21-0.25 SD) decrease in accuracy that did not survive adjustment for multiple testing and no change in speed (0.00-0.12 SD) across cognitive domains in the supine and -12 degrees HDT position relative to upright. A true decrease in speed may have been masked by practice effects, as speed was found to increase by 0.06 SD per test bout in condition (95% confidence interval 0.03; 0.10). Performance differences between -12 degrees HDT and supine positions across cognitive domains were less than small ( 0.2 SD) according to conventional standards.Discussion: This study on short-term positional changes on cognitive performance suggests that performing Cognition in the supine or -12 degrees HDT position on a tablet is associated with small decreases in accuracy and, if practice effects are taken into account, potentially also speed, but with no relevant differences between positions. These findings help interpret bed rest studies that use the new -12 degrees HDT paradigm.
机译：背景：微重力诱导的流体移位和所得脑血流动力学的变化可以与太空型的认知性能改变相关联。下倾斜（HDT）卧床休息用作微匍匐诱导的头部液体移位的经过验证的空云模拟。本研究检测了短期（T <4 H）变化在身体位置（仰卧或-12度HDT）的影响相对于认知性能的45度直立位置。方法：在这个受试者内交叉研究中，十个男性受试者没有重要的医疗合并症（平均+/-标准偏差[SD]年龄：34岁+/- 3，重量：81 kg +/- 11，高度：1.77 m +/- 0.06，体重指数：26公斤/ m（2）+/- 3）在-12度HDT或仰卧位的1,2,3和4小时之后，在基线（45度直立），在-12摄氏度或仰卧位，在30℃下进行认知测试电池，30-分钟恢复在45度直立位置。条件（-12℃或仰卧）的顺序被随机化，在测试日之间具有> 1周的冲洗。结果：Z转换认知测试分数的混合模型分析表明，小（0.21-0.25 SD）的准确性降低在仰卧的仰角和-12度HDT位置的认知域中没有速度调整，并且在仰卧的认知域中没有变化（0.00-0.12 sd）。速度的真实减少可能通过实践效果掩盖，因为发现速度在条件下每次测试速度增加0.06 SD（95％置信区间0.03; 0.10）。根据传统标准，认知结构域之间的性能差异为-12度HDT和仰卧位的差异小于小（<0.2 SD）。探讨：这项关于认知性能的短期位置变化的研究表明，在仰卧或-12中表现认知平板电脑上的HDT位置与精度下降有关，并且如果考虑实践效果，可能也速度，但位置之间没有相关差异。这些发现有助于解释床休息研究，该研究使用新-12度HDT范例。

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