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Language and reading abilities of children with autism spectrum disorders and specific language impairment and their first-degree relatives

机译：自闭症谱系障碍和特定语言障碍儿童及其一级亲属的语言和阅读能力

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摘要

Autism spectrum disorder (ASD) and specific language impairment (SLI) are developmental disorders exhibiting language deficits, but it is unclear whether they arise from similar etiologies. Language impairments have been described in family members of children with ASD and SLI, but few studies have quantified them. In this study, we examined IQ, language, and reading abilities of ASD and SLI children and their first-degree relatives to address whether the language difficulties observed in some children with ASD are familial and to better understand the degree of overlap between these disorders and their broader phenotypes. Participants were 52 autistic children, 36 children with SLI, their siblings, and their parents. The ASD group was divided into those with (ALI, n=32) and without (ALN, n=20) language impairment. Relationships between ASD severity and language performance were also examined in the ASD probands. ALI and SLI probands performed similarly on most measures while ALN probands scored higher. ALN and ALI probands' language scores were not related to Autism Diagnostic Interview - Revised and Autism Diagnostic Observation Schedule algorithm scores. SLI relatives scored lowest on all measures, and while scores were not in the impaired range, relatives of ALI children scored lower than relatives of ALN children on some measures, though not those showing highest heritability in SLI. Given that ALI relatives performed better than SLI relatives across the language measures, the hypothesis that ALI and SLI families share similar genetic loading for language is not strongly supported.
机译：自闭症谱系障碍（ASD）和特定语言障碍（SLI）是表现出语言缺陷的发育障碍，但尚不清楚它们是否源于相似的病因。在患有ASD和SLI的儿童的家庭成员中已经描述了语言障碍，但是很少有研究对其进行量化。在这项研究中，我们检查了ASD和SLI儿童及其一级亲属的智商，语言和阅读能力，以解决在某些ASD儿童中观察到的语言障碍是否是家族性的，并更好地了解这些障碍与儿童之间的重叠程度。他们更广泛的表型。参加者为52名自闭症儿童，36名SLI儿童，其兄弟姐妹及其父母。 ASD组分为（ALI，n = 32）和无（ALN，n = 20）语言障碍者。 ASD先证者还检查了ASD严重程度与语言表现之间的关系。 ALI和SLI先证者在大多数指标上的表现相似，而ALN先证者得分更高。 ALN和ALI先证者的语言成绩与“自闭症诊断访谈-修订版”和“自闭症诊断观察时间表”算法分数无关。 SLI亲属在所有指标上得分最低，虽然得分不在受损范围内，但在某些指标上，ALI儿童的亲戚得分低于ALN儿童的亲戚，尽管在SLI中遗传力最高的不是。考虑到ALI亲属在所有语言指标上的表现均优于SLI亲属，因此，关于ALI和SLI家族对语言的遗传负载相似的假设的支持不强。

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    《Autism Research》 |2009年第1期|22-38|共17页
  • 作者

    Kristen A. Lindgren; Susan E. Folstein; J. Bruce Tomblin; Helen Tager-Flusberg;

  • 作者单位

    Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, Massachusetts;

    Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, Maryland;

    Department of Speech Pathology and Audiology, University of Iowa, Iowa City, Iowa;

    Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, Massachusetts;

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