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首页> 外文期刊>Behavior Genetics >Cannabis and Other Illicit Drugs: Comorbid Use and Abuse/Dependence in Males and Females
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Cannabis and Other Illicit Drugs: Comorbid Use and Abuse/Dependence in Males and Females

机译：大麻和其他非法药物：男女混用和滥用/依赖性

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摘要

Cannabis and other illicit drugs are often used or abused comorbidly. Two competing theories to explain this comorbidity are (i) the phenotypic causation (gateway) model and (ii) the correlated liabilities model. We used data from 1191 male and 934 female same-sex twin pairs to test 13 genetically informative models of comorbidity. Models were fit separately for use and abuse/dependence in both sexes. The correlated liabilities model provided a good fit to the data for cannabis and other illicit drug use, as well as abuse/dependence. The relationship between the use or abuse of cannabis and other illicit drugs is not entirely phenotypic, as depicted by the random multiformity of cannabis model, which is an adaptation of the gateway model. The comorbidity appears to arise from correlated genetic and environmental influences. There is some evidence for a model in which high-risk cannabis users may be at increased risk for other illicit drug use. For abuse/dependence, a model with causal pathways between the liability for cannabis and other illicit drug abuse/dependence also fits well. Overall, our results suggest that the use and abuse/dependence of cannabis and other illicit drugs are strongly linked via common risk factors that jointly influence their individual liabilities.
机译：大麻和其他非法药物经常被合并使用或滥用。两种解释该合并症的相互竞争的理论是（i）表型因果（网关）模型和（ii）相关负债模型。我们使用来自1191男性和934女性同性双胞胎对的数据来测试13种合并症的遗传信息模型。模型分别适合于男女的使用和滥用/依赖性。相关负债模型非常适合大麻和其他非法药物使用以及滥用/依赖的数据。大麻和其他非法药物的使用或滥用之间的关系并不完全是表型，如对大麻模型的适应，即大麻模型的随机多态性所描绘的。合并症似乎是由相关的遗传和环境影响引起的。有一种证据表明，高风险大麻使用者使用其他非法药物的风险可能增加。对于滥用/依赖，在大麻责任与其他非法药物滥用/依赖之间具有因果关系的模型也很合适。总体而言，我们的结果表明，大麻和其他非法药物的使用和滥用/依赖性通过共同影响其个人责任的常见风险因素而紧密相关。

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  • 来源
    《Behavior Genetics》 |2004年第3期|217-228|共12页
  • 作者

    Arpana Agrawal; Michael C. Neale; Carol. A. Prescott; Kenneth S. Kendler;

  • 作者单位

    Department of Human Genetics Medical College of Virginia of Virginia Commonwealth University Virginia Institute for Psychiatric and Behavioral Genetics;

    Department of Human Genetics Medical College of Virginia of Virginia Commonwealth University Virginia Institute for Psychiatric and Behavioral GeneticsDepartment of Psychiatry Medical College of Virginia of Virginia Commonwealth University Virginia Institute for Psychiatric and Behavioral Genetics;

    Department of Psychiatry Medical College of Virginia of Virginia Commonwealth University Virginia Institute for Psychiatric and Behavioral Genetics;

    Department of Human Genetics Medical College of Virginia of Virginia Commonwealth University Virginia Institute for Psychiatric and Behavioral GeneticsDepartment of Psychiatry Medical College of Virginia of Virginia Commonwealth University Virginia Institute for Psychiatric and Behavioral Genetics;

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  • 正文语种 eng
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  • 关键词

    Twins; comorbidity; cannabis; illicit drugs; use; abuse/dependence;

    机译：双胞胎;合并症;大麻;非法药物;使用;滥用/依赖性;

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