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首页> 外文期刊>Biochemical Genetics >Role of HLA Allele Polymorphism in Chronic Hepatitis B Virus Infection and HBV Vaccine Sensitivity in Patients from Eastern Turkey
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Role of HLA Allele Polymorphism in Chronic Hepatitis B Virus Infection and HBV Vaccine Sensitivity in Patients from Eastern Turkey

机译：HLA等位基因多态性在土耳其东部患者慢性乙型肝炎病毒感染和HBV疫苗敏感性中的作用

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摘要

Human leukocyte antigen (HLA) alleles have been associated with the clinical outcomes of hepatitis B virus (HBV) infection, which range from spontaneous recovery to hepatocellular carcinoma. In this study involving subjects from eastern Turkey, the frequencies of HLA-B35, HLA-CW4, HLA-DQ2, and HLA-DQ8 were markedly higher in the chronic HBV group than those in the spontaneously recovered group; the frequencies of HLA-A11 and HLA-A24 in the nonresponsive HBV vaccine group were markedly higher than those in the responsive HBV vaccine group; and the frequency of HLA-CW6 in the nonresponsive HBV vaccine group was significantly lower than in the responsive group. A complete understanding of HLA types associated with the progression to chronic HBV infection and their effects within the cell at the molecular level will be an important contribution in the development of new HBV vaccines and new treatment strategies for chronic HBV infection.
机译：人类白细胞抗原（HLA）等位基因与乙型肝炎病毒（HBV）感染的临床结果相关，其范围从自然恢复到肝细胞癌。在这项涉及土耳其东部受试者的研究中，慢性HBV组的HLA-B35，HLA-CW4，HLA-DQ2和HLA-DQ8的频率显着高于自发恢复组。无反应的HBV疫苗组的HLA-A11和HLA-A24的频率明显高于有反应的HBV疫苗组。无反应的HBV疫苗组的HLA-CW6频率明显低于有反应的组。全面了解与慢性HBV感染进展有关的HLA类型及其在分子水平上在细胞内的作用，将为新的HBV疫苗的开发和慢性HBV感染的新治疗策略做出重要贡献。

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