Population Research of Genetic Polymorphism at Amino Acid Position 631 in Chicken Mx Protein with Differential Antiviral Activity

T. Seyama; J. H. Ko; M. Ohe; N. Sasaoka; A. Okada; H. Gomi; A. Yoneda; J. Ueda; M. Nishibori; S. Okamoto; Y. Maeda; T. Watanabe

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Population Research of Genetic Polymorphism at Amino Acid Position 631 in Chicken Mx Protein with Differential Antiviral Activity

机译：具有差异抗病毒活性的鸡Mx蛋白氨基酸631位点遗传多态性研究

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A single amino acid substitution between Asn and Ser at position 631 in the chicken Mx protein has been reported to determine resistant and sensitive antiviral activity. In this study, we investigate whether various kinds of chicken breeds and jungle fowls carry the resistant or sensitive Mx allelic gene by using the mismatched PCR-restriction fragment length polymorphism (RFLP) technique. In total, 271 samples from 36 strains of 17 chicken breeds and from 3 kinds of jungle fowls were examined. The rates of the resistant Mx gene and sensitive gene were 59.2% and 40.8%, respectively. Only a Red jungle fowl captured in Laos carried the resistant Mx gene, and the other three Red jungle fowls from Indonesia and Gray and Green jungle fowls all had the sensitive Mx gene. These results were confirmed by the determination of amino acid sequences in the GTPase effector domain of jungle fowls.

机译：据报道，鸡Mx蛋白中631位Asn和Ser之间存在单个氨基酸取代，可以确定抗药性和敏感性抗病毒活性。在这项研究中，我们通过使用错配的PCR限制性片段长度多态性（RFLP）技术来研究各种鸡品种和野禽是否携带抗性或敏感的Mx等位基因。总共检查了来自17种鸡的36个品系和3种野禽的271个样本。抗性Mx基因和敏感基因的发生率分别为59.2％和40.8％。老挝只捕获了一个红色丛林家禽带有抗性Mx基因，印度尼西亚的另外三个红色丛林家禽和灰色和绿色丛林家禽都具有敏感的Mx基因。通过确定野禽的GTPase效应子域中的氨基酸序列，证实了这些结果。

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来源
《Biochemical Genetics》 |2006年第10期|432-443|共12页
作者
T. Seyama; J. H. Ko; M. Ohe; N. Sasaoka; A. Okada; H. Gomi; A. Yoneda; J. Ueda; M. Nishibori; S. Okamoto; Y. Maeda; T. Watanabe;
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作者单位

Graduate School of Agriculture Hokkaido University Sapporo 060-8589 Japan;

Graduate School of Agriculture Hokkaido University Sapporo 060-8589 Japan;

Graduate School of Agriculture Hokkaido University Sapporo 060-8589 Japan;

Graduate School of Agriculture Hokkaido University Sapporo 060-8589 Japan;

Graduate School of Agriculture Hokkaido University Sapporo 060-8589 Japan;

Graduate School of Agriculture Hokkaido University Sapporo 060-8589 Japan;

Graduate School of Agriculture Hokkaido University Sapporo 060-8589 Japan;

Graduate School of Agriculture Hokkaido University Sapporo 060-8589 Japan;

Laboratory of Animal Breeding and Genetics Hiroshima University Higashihiroshima 739-8528 Japan;

Faculty of Agriculture Kagoshima University Kagoshima 890-0065 Japan;

Faculty of Agriculture Kagoshima University Kagoshima 890-0065 Japan;

Graduate School of Agriculture Hokkaido University Sapporo 060-8589 Japan;

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正文语种 eng
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关键词
chicken; jungle fowl; Mx gene; polymorphism; antiviral gene; PCR-RFLP;

机译：鸡;丛林禽;Mx基因;多态性;抗病毒基因;PCR-RFLP;

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专利

1. Both antiviral activity and intracellular localization of chicken Mx protein depend on a polymorphism at amino acid position 631 [J] . SasakiK., YonedaA., NinomiyaA., Biochemical and Biophysical Research Communications . 2013,第1期

机译：抗病毒活性和鸡MX蛋白的细胞内定位依赖于氨基酸位置631的多态性
2. Susceptibility of different chicken lines to H7N1 highly pathogenic avian influenza virus and the role of Mx gene polymorphism coding amino acid position 631. [J] . Sironi L, Williams JL, Moreno-Martin AM, Virology . 2008,第1期

机译：不同鸡系对H7N1高致病性禽流感病毒的敏感性以及编码氨基酸631位的Mx基因多态性的作用。
3. Ontogenic Expression Pattern and Genetic Polymorphisms of the Fatty Acid Transport Protein 4 (FATP4) Gene in Chinese Chicken Populations [J] . Ling Yang, Qing Zhu, Yan Wang, International Journal of Molecular Sciences . 2012,第6期

机译：中国鸡种群脂肪酸转运蛋白4（FATP4）基因的本体表达模式和遗传多态性
4. The extrinsic 18-kDa protein in Photosystem II restores the ion-retention activity of a mutant extrinsic 23-kDa protein lacking 19 amino-acid residues on the amino terminus [C] . K Ifuku, T Nakatu, H Kato, International Congress on Photosynthesis . 2001

机译：照相中的18-kda蛋白II中恢复突变物外在的23-kda蛋白的离子保留活性，缺乏19个氨基酸残基的氨基末端
5. Genetic Control of Protein and Amino Acid Content in Soybean Determined in Two Genetically Connected Populations. [D] . Carlson, Carrin Marie. 2011

机译：在两个遗传相关群体中确定的大豆蛋白质和氨基酸含量的遗传控制。
6. Polymorphisms and the Differential Antiviral Activity of the Chicken Mx Gene [O] . Jae-Hong Ko, Hee-Kyung Jin, Atsushi Asano, 2002

机译：鸡Mx基因的多态性和差异抗病毒活性
7. Both antiviral activity and intracellular localization of chicken Mx protein depend on a polymorphism at amino acid position 631 [O] . Sasaki, Keisuke, Yoneda, Akihiro, Ninomiya, Akinori, 2013

机译：鸡Mx蛋白的抗病毒活性和细胞内定位均取决于氨基酸631位的多态性

Population Research of Genetic Polymorphism at Amino Acid Position 631 in Chicken Mx Protein with Differential Antiviral Activity

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