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首页> 外文期刊>Biochemical Genetics >Gene Frequency Distribution of the BoLA-DRB3 Locus in Saavedreño Creole Dairy Cattle
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Gene Frequency Distribution of the BoLA-DRB3 Locus in Saavedreño Creole Dairy Cattle

机译：Saavedreño克里奥尔人奶牛的BoLA-DRB3基因座的基因频率分布

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摘要

The objective of this study is to describe the gene frequency distribution of the bovine lymphocyte antigen (BoLA)-DRB3 locus in Saavedreño Creole dairy cattle and to compare it with previously reported patterns in other cattle breeds. One hundred and twenty-five Saavedreño Creole dairy cattle were genotyped for the BoLA-DRB3.2 allele by polymerase chain reaction and restriction fragment length polymorphism. Twenty-two out of 53 previously identified BoLA-DRB3.2 alleles were detected, with gene frequencies ranging from 0.4 to 16.8%. Seventy percent of the variation corresponded to the seven most frequent alleles (BoLA-DRB3.2*7, *8, *11, *16, *27, *36, and *37). The studied population exhibits a high degree of expected heterozygosity (h e = 0.919). The F IS index did not show significant deviation from Hardy-Weinberg equilibrium. However, the neutrality test showed an even gene frequency distribution. This result could be better explained assuming balancing selection instead of neutral or positive selection for one or a few alleles. In conclusion, the results of this study demonstrated that BoLA-DRB3.2 is a highly polymorphic locus in Saavedreño Creole dairy cattle, with significant variation in allele frequency among cattle breeds.
机译：这项研究的目的是描述SaavedreñoCreole奶牛的牛淋巴细胞抗原（BoLA）-DRB3基因座的基因频率分布，并将其与以前报道的其他牛种中的模式进行比较。通过聚合酶链反应和限制性片段长度多态性，对125个SaavedreñoCreole奶牛的BoLA-DRB3.2等位基因进行基因分型。在先前鉴定的53个BoLA-DRB3.2等位基因中，有22个被检测到，基因频率范围为0.4％至16.8％。 70％的变异对应于七个最常见的等位基因（BoLA-DRB3.2 * 7，* 8，* 11，* 16，* 27，* 36和* 37）。所研究的人群表现出很高的预期杂合度（h e = 0.919）。 F IS 指数与Hardy-Weinberg平衡没有显着偏离。但是，中性测试显示出均匀的基因频率分布。假设为一个或几个等位基因选择平衡选择而不是中性或阳性选择，则可以更好地解释此结果。总之，这项研究的结果表明，BoLA-DRB3.2是SaavedreñoCreole奶牛的高度多态性基因座，牛种之间的等位基因频率存在显着差异。

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  • 来源
    《Biochemical Genetics》 |2004年第8期|231-240|共10页
  • 作者

    M. V. Ripoli; J. P. Lirón; J. C. De Luca; F. Rojas; F. N. Dulout; G. Giovambattista;

  • 作者单位

    Centro de Investigaciones en Genética Básica y Aplicada (CIGEBA) Facultad de Ciencias Veterinarias Universidad Nacional de La Plata;

    Centro de Investigaciones en Genética Básica y Aplicada (CIGEBA) Facultad de Ciencias Veterinarias Universidad Nacional de La Plata;

    Centro de Investigaciones en Genética Básica y Aplicada (CIGEBA) Facultad de Ciencias Veterinarias Universidad Nacional de La Plata;

    Av. Ejercito Nacional 131;

    Centro de Investigaciones en Genética Básica y Aplicada (CIGEBA) Facultad de Ciencias Veterinarias Universidad Nacional de La Plata;

    Centro de Investigaciones en Genética Básica y Aplicada (CIGEBA) Facultad de Ciencias Veterinarias Universidad Nacional de La Plata;

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  • 正文语种 eng
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  • 关键词

    BoLA-DRB3.2; Creole cattle; PCR-RFLP; genetic diversity;

    机译：BoLA-DRB3.2;克里奥尔牛;PCR-RFLP;遗传多样性;

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