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首页> 外文期刊>Biochemistry >Relationships among Visual Cycle Retinoids, Rhodopsin Phosphorylation, and Phototransduction in Mouse Eyes during Light and Dark Adaptation
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Relationships among Visual Cycle Retinoids, Rhodopsin Phosphorylation, and Phototransduction in Mouse Eyes during Light and Dark Adaptation

机译：在明暗适应过程中小鼠眼睛的视觉周期类维生素A，视紫红质磷酸化和光转导之间的关系。

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摘要

Phosphorylation and regeneration of rhodopsin, the prototypical G-protein-coupled receptor,neach can influence light and dark adaptation. To evaluate their relative contributions, we quantifiednrhodopsin, retinoids, phosphorylation, and photosensitivity in mice during a 90 min illumination followednby dark adaptation. During illumination, all-trans-retinyl esters and, to a lesser extent, all-trans-retinalnaccumulate and reach the steady state in <1 h. Each major phosphorylation site on rhodopsin reaches ansteady state level of phosphorylation at a different time during illumination. The dominant factor that limitsndark adaptation is isomerization of retinal. During dark adaptation, dephosphorylation of rhodopsin occursnin two phases. The faster phase corresponds to rapid dephosphorylation of regenerated rhodopsin present atnthe end of the illumination period. The slower phase corresponds to dephosphorylation of rhodopsin as itnforms by regeneration. We conclude that rhodopsin phosphorylation has three physiological functions: itnquenches phototransduction, reduces sensitivity during light adaptation, and suppresses bleached rhodopsinnactivity during dark adaptation.
机译：原型G蛋白偶联受体视紫红质的磷酸化和再生均会影响明暗适应。为了评估它们的相对作用，我们在90分钟光照后进行暗适应后，对小鼠中的视紫红质，类维生素A，磷酸化和光敏性进行了定量。在光照过程中，全反式维甲酸酯以及较小程度的全反式维甲酸积累并在不到1小时的时间内达到稳态。视紫红质上的每个主要磷酸化位点在照明期间的不同时间达到稳定状态的磷酸化水平。限制ndark适应性的主要因素是视网膜的异构化。在黑暗适应过程中，视紫红质的去磷酸化发生在两个阶段。更快的阶段对应于在照明周期结束时存在的再生视紫红质的快速去磷酸化。较慢的相对应于视紫红质通过再生而去磷酸化。我们得出的结论是，视紫红质的磷酸化具有三种生理功能：抑制光转导，降低光适应过程中的敏感性，并抑制暗适应过程中漂白的视紫红质活性。

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