Regioselectivity in the Homolytic Cleavage of S-Adenosylmethionine

Jack A. Kampmeier

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Regioselectivity in the Homolytic Cleavage of S-Adenosylmethionine

机译：S-腺苷甲硫氨酸的均质裂解中的区域选择性

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The observed regioselectivity of the homolytic cleavage of S-adenosylmethionine (SAM) by thenradical SAM enzymes is modeled by free radical displacement reactions at sulfoxide centers. Thesendisplacements are also regioselective, in direct consequence of the reaction mechanism. The selectivity innthe radical SAMreactions is explained by the geometry of the free radical displacement mechanism, requirednby the chemical reaction and arranged in the active site by the radical SAM proteins.

机译：自由基SAM酶对S-腺苷甲硫氨酸（SAM）的均相裂解的区域选择性观察是通过亚砜中心的自由基置换反应进行建模的。由于反应机理的直接结果，感觉置换也是区域选择性的。自由基SAM反应的选择性是由自由基置换机制的几何结构解释的，是化学反应所必需的，并且由自由基SAM蛋白排列在活性位点上。

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《Biochemistry》 |2010年第51期|p.10770-10772|共3页
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Jack A. Kampmeier;
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Department of Chemistry, University of Rochester, Rochester, New York 14627-0216, United States;

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1. Regioselectivity in the Homolytic Cleavage of S-Adenosylmethionine [J] . Kampmeier JA Biochemistry . 2010,第51期

机译：S-腺苷甲硫氨酸均质裂解中的区域选择性
2. Active-Site Controlled, Jahn-Teller Enabled Regioselectivity in Reductive S-C Bond Cleavage of S-Adenosylmethionine in Radical SAM Enzymes [J] . Stella Impano, Hao Yang, Richard J. Jodts, Journal of the American Chemical Society . 2021,第1期

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3. Mass spectrometric and theoretical studies on dissociation of the SS bond in the allicin: Homolytic cleavage vs heterolytic cleavage [J] . Zhang X. Journal of Molecular Structure . 2012,第Null期

机译：大蒜素中SS键解离的质谱和理论研究：均质裂解与杂合裂解
4. Homolytic Cleavage of Radicals and Ion-Radicals as Intramolecular Dissociative Electron Transfer [C] . Cvrille Costentin, Marc Robert, Jean-Michel Saveant The Meeting of the Electrochemical Society . 2003

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Regioselectivity in the Homolytic Cleavage of S-Adenosylmethionine

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