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2-Aminoimidazoles as potent inhibitors of contaminating brewery biofilms

机译：2-氨基咪唑作为污染啤酒生物膜的有效抑制剂

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摘要

Cleaning and disinfection protocols are not always able to remove biofilm microbes present in breweries, indicating that novel anti-biofilm strategies are needed. The preventive activities of three in-house synthesized members of the 2-aminoimidazole class of anti-biofilm molecules were studied against 17 natural brewery biofilms and benchmarked against 18 known inhibitors. Two 2-aminoimidazoles belonged to the top six inhibitors, which were retested against 12 defined brewery biofilm models. For the three best inhibitors, tannic acid (n degrees 1), 2-aminoimidazole imi-AAC-5 (n degrees 2), and baicalein (n degrees 3), the effect on the microbial metabolic activity was evaluated. Here, the top three inhibitors showed similar effectiveness, with baicalein possessing a slightly higher efficacy. Even though the 2-aminoimidazole was the second-best inhibitor, it showed a lower biocidal activity than tannic acid, making it less prone to resistance evolution. Overall, this study supports the potential of 2-aminoimidazoles as a preventive anti-biofilm strategy.
机译：清洁和消毒方案并不总是能够去除啤酒厂中存在的生物膜微生物，表明需要新型抗生物膜策略。研究了三种内部咪唑类抗生物膜分子的三个内部合成成员的预防活性，针对17个天然酿酒厂生物膜，并针对18名已知的抑制剂基准测试。两种2-氨基咪唑属于前六个抑制剂，其被重新测试，以反对12个定义的啤酒厂生物膜模型。对于三种最佳抑制剂，单宁酸（N型1），2-氨基咪唑IMI-AAC-5（n级2）和Baicalin（n级3），评价对微生物代谢活性的影响。在这里，前三个抑制剂表现出类似的有效性，Baicalein具有略微更高的疗效。尽管2-氨基咪唑是第二次最佳抑制剂，但它表现出比单宁酸的杀生物活性较低，使其易于易于抗性进化。总体而言，本研究支持2-氨基咪唑的潜力作为预防性抗生物膜策略。

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  • 来源
    《Biofouling》 |2021年第2期|61-77|共17页
  • 作者

    Jacobs Lene; Meesters Jolien; Parijs Ilse; Hooyberghs Geert; Van der Eycken Erik V.; Lories Bram; Steenackers Hans P.;

  • 作者单位

    Katholieke Univ Leuven Ctr Microbial & Plant Genet Leuven Belgium;

    Katholieke Univ Leuven Ctr Microbial & Plant Genet Leuven Belgium;

    Katholieke Univ Leuven Ctr Microbial & Plant Genet Leuven Belgium;

    Katholieke Univ Leuven Lab Organ & Microwave Assisted Chem LOMAC Leuven Belgium;

    Katholieke Univ Leuven Lab Organ & Microwave Assisted Chem LOMAC Leuven Belgium|Peoples Friendship Univ Russia RUDN Univ Moscow Russia;

    Katholieke Univ Leuven Ctr Microbial & Plant Genet Leuven Belgium;

    Katholieke Univ Leuven Ctr Microbial & Plant Genet Leuven Belgium;

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  • 原文格式 PDF
  • 正文语种 eng
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  • 关键词

    2-aminoimidazole; inhibitor; brewery; biofilm; screening; benchmarking;

    机译：2-氨基咪唑;抑制剂;啤酒厂;生物膜;筛选;基准测试;

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