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Bacteriophages as tools for biofilm biocontrol in different fields

机译:噬菌体作为不同领域的生物膜生物电力的工具

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摘要

Microbial biofilms are difficult to control due to the limited accessibility that antimicrobial drugs and chemicals have to the entrapped inner cells. The extracellular matrix, binds water, contributes to altered cell physiology within biofilms and act as a barrier for most antiproliferative molecules. Thus, new strategies need to be developed to overcome biofilm vitality. In this review, based on 223 documents, the advantages, recommendations, and limitations of using bacteriophages as 'biofilm predators' are presented. The plausibility of using phages (bacteriophages and mycoviruses) to control biofilms grown in different environments is also discussed. The topics covered here include recent historical experiences in biofilm control/eradication using phages in medicine, dentistry, veterinary, and food industries, the pros and cons of their use, and the development of microbial resistance/immunity to such viruses.
机译:由于抗微生物药物和化学物质对夹带的内细胞有限,微生物生物膜难以控制。 细胞外基质结合水,有助于生物膜内的改变细胞生理学,并充当大多数抗增殖分子的屏障。 因此,需要开发新的策略来克服生物膜生命力。 在本次审查中,提出了基于223个文件,使用噬菌体作为“生物膜捕食者”的优点,建议和局限性。 还讨论了使用噬菌体(噬菌体和菌病毒)来控制在不同环境中生长的生物膜的合理性。 这里涉及的主题包括最近在生物膜控制/消除药物,牙科,兽医和食品行业,使用的优点和缺点的历史经验,以及它们的利弊以及这种病毒的微生物抗性/免疫力的发展。

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