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首页> 外文期刊>Bioinspired, biomimetic and nanobiomaterials >Heparin-grafted PVA hydrogels: a material for the optical part of artificial cornea
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Heparin-grafted PVA hydrogels: a material for the optical part of artificial cornea

机译：肝素移植的PVA水凝胶：一种用于人造角膜光学部分的材料

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摘要

Heparin (Hep) was grafted to a poly(vinyl alcohol) (PVA) hydrogel surface by using the covalent grafting method. The structure of the modified hydrogel was determined from Fourier transform infrared attenuated total reflection and X-ray photoelectron spectroscopy. The thermal stability of the samples was investigated by thermogravimetry-differential thermal analysis. The effects of the concentration of (3-aminopropyl)triethoxysilane (kh550) and Hep on visible light transmittance, moisture content, equilibrium swelling, hydrophilicity and percentage of Hep sodium release of the composite hydrogel were studied. The visible light transmittance of the modified PVA hydrogel was above 94%. The time of swelling equilibrium was about 60 min and the equilibrium swelling ratio ranged from 3.0 to 3.5. The hydrophilicity was enhanced, and the static water contact angle decreased from 41 to 28 degrees. The bioeffects of the PVA-kh550-Hep hydrogel were evaluated by studying cell adhesion and proliferation. During the adhesion assay in vitro, cell adhesion significantly decreased after the interfaces had been modified with Hep. The Cell Counting Kit-8 assay showed that the biocompatibility of the PVA-kh550-Hep hydrogel improved obviously compared to that of pure PVA. The experimental results demonstrated that the PVA-kh550-Hep hydrogel had good stability, bioactivity and biocompatibility, suggesting its potential applications in artificial corneas.
机译：通过使用共价接枝方法将肝素（Hep）接枝到聚乙烯醇（PVA）水凝胶表面。改性水凝胶的结构由傅里叶变换红外衰减全反射和X射线光电子能谱确定。通过热重分析-差热分析研究样品的热稳定性。研究了（3-氨基丙基）三乙氧基硅烷（kh550）和Hep的浓度对复合水凝胶的可见光透射率，水分含量，平衡溶胀，亲水性和Hep钠释放百分比的影响。改性的PVA水凝胶的可见光透射率高于94％。溶胀平衡的时间为约60分钟，且溶胀平衡比为3.0至3.5。亲水性增强，静态水接触角从41度降低到28度。通过研究细胞粘附和增殖评估了PVA-kh550-Hep水凝胶的生物效应。在体外粘附测定期间，用Hep修饰界面后，细胞粘附显着降低。 Cell Counting Kit-8分析表明，与纯PVA相比，PVA-kh550-Hep水凝胶的生物相容性明显提高。实验结果表明，PVA-kh550-Hep水凝胶具有良好的稳定性，生物活性和生物相容性，表明其在人工角膜中的潜在应用。

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