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首页> 外文期刊>Biological Trace Element Research >Pharmacokinetics, Tissue Distribution, and Plasma Protein Binding Study of Platinum Originating from Dicycloplatin, a Novel Antitumor Supramolecule, in Rats and Dogs by ICP-MS
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Pharmacokinetics, Tissue Distribution, and Plasma Protein Binding Study of Platinum Originating from Dicycloplatin, a Novel Antitumor Supramolecule, in Rats and Dogs by ICP-MS

机译：ICP-MS研究铂和双环铂（一种新型的抗肿瘤超分子）在大鼠和狗中的药代动力学，组织分布和血浆蛋白结合研究

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Dicycloplatin, as a new antitumor supramolecule, was considered to have higher solubility and higher stability compared with carboplatin. The aim of the present study was to evaluate the pharmacokinetic characteristics of platinum originating from dicycloplatin. A rapid, sensitive, and specific method with inductively coupled plasma mass spectrometry (ICP-MS) has been developed for the determination of platinum in bio-samples. The study was performed in male rats and dogs at a single dose of 10 and 5 mg kg−1 separately by intravenous injection. Pharmacokinetic parameters were calculated by non-compartmental method, and the dose of platinum was used in the calculation of these parameters. Results showed that plasma concentrations of platinum began to decrease rapidly initially but decline slowly with a long terminal phase. The mean half-life was 27.39 and 100.98 and clearance was 0.77 and 0.08 L/h/kg for rats and dogs separately. Tissue distribution showed that platinum originating from dicycloplatin had a certain distribution in testis and prostate. Plasma protein binding proportion of platinum was increased with time. In conclusion, this research investigated the pharmacokinetic characteristics including plasma kinetics, tissue distribution, and plasma protein binding of platinum originating from dicycloplatin in rats and dogs in detail for the first time by ICP-MS.
机译：双环铂作为一种新的抗肿瘤超分子，被认为比卡铂具有更高的溶解度和更高的稳定性。本研究的目的是评估源自二环铂的铂的药代动力学特征。已经开发了一种快速，灵敏且特定的电感耦合等离子体质谱法（ICP-MS），用于测定生物样品中的铂。通过静脉内注射分别在雄性大鼠和狗中分别以10和5 mg kg -1 的剂量进行此项研究。通过非房室方法计算药代动力学参数，并使用铂的剂量计算这些参数。结果表明，铂的血浆浓度最初开始迅速下降，但随着较长的终期逐渐下降。大鼠和狗的平均半衰期分别为27.39和100.98，清除率分别为0.77和0.08 L / h / kg。组织分布表明，源自二环铂的铂在睾丸和前列腺中具有一定的分布。铂的血浆蛋白结合比例随时间增加。总之，本研究首次通过ICP-MS详细研究了大鼠和狗体内源自双环铂的铂的药代动力学特征，包括血浆动力学，组织分布和血浆蛋白结合。

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