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Comparative Structural Analysis of Myosin Light Chains and Gene Duplication in Fish

机译：鱼中肌球蛋白轻链和基因复制的比较结构分析

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摘要

Origin and structure of myosin light chain (MLC) proteins have been studied by comparative analysis of fish mlc1, mlc2, and mlc3 genes encoding MLC1, MLC2, and MLC3, respectively. The exon-intron structure of these genes has been analyzed in zebrafish Danio rerio, loach Misgurnus fossilis, fugu Takifugu rubripes, and Nile puffer Tetraodon fahaka. We propose that mlc1 and mlc3 are homologues genes originated by fish-specific whole genome duplication (paralogs). This is supported by high sequence similarity between mlc1 and mlc3 as well as by the exon-intron structure of these genes and their localization on different chromosomes. Exons 2 to 5 of mlc1 and mlc3 are highly conserved and have similar splicing sites. A paralog gene of mlc2 resulting from a similar duplication event has been identified in zebrafish genome. Expression of mlc1 paralog is limited to the larval stages of Danio rerio and to regenerating tissues of the adult fish. There is a possibility that the paralog of mlc1 encodes larval myosin light chain protein (larval MLC) previously reported in a number of fish species.
机译：已通过对分别编码MLC1，MLC2和MLC3的鱼mlc1，mlc2和mlc3基因进行比较分析，研究了肌球蛋白轻链（MLC）蛋白的起源和结构。这些基因的外显子-内含子结构已在斑马鱼Danio rerio，泥ach Misgurnus化石，河豚Takifugu rubripes和尼罗河豚Tetraodon fahaka中进行了分析。我们建议mlc1和mlc3是由鱼类特异性全基因组复制（旁系同源物）起源的同源基因。 mlc1和mlc3之间的高度序列相似性以及这些基因的外显子-内含子结构及其在不同染色体上的定位支持了这一点。 mlc1和mlc3的外显子2至5是高度保守的，并具有相似的剪接位点。已经在斑马鱼基因组中鉴定了由类似的复制事件产生的mlc2的旁系同源基因。 mlc1旁系同源物的表达仅限于达尼奥里奥幼虫阶段和成年鱼的再生组织。 mlc1的旁系同源物可能编码先前在许多鱼类中报道的幼虫肌球蛋白轻链蛋白（幼虫MLC）。

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  • 来源
    《Biology Bulletin》 |2006年第1期|p.30-34|共5页
  • 作者

    N. S. Mugue; N. D. Ozernyuk;

  • 作者单位

    Kol'tsov Institute of Developmental Biology, Russian Academy of Sciences, ul. Vavilova 26, Moscow, 119991 Russia;

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  • 正文语种 eng
  • 中图分类 生物科学;
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