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The Hypothesis of Immune Testing of Partners—Friend/Foe Identification Systems in Historical Perspective

机译:伴侣免疫测试假说的历史视角

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摘要

The hypothesis of "autoimmune testing" of mating partners assumes the formation of an immune-based individual perception system involving intravital selection of direct or inverse replica of self key antigens or alarm molecules. Such system ensures coordinated changes of the signaling system and system of signal perception as new adaptations appear, which automatically provides for reproductive isolation within a limited number of generations. The presence of the friend/foe identification systems in nearly all living organisms suggests the formation of the mechanisms of autoimmune testing of potential mating partners at the earliest stages of evolution. Possible mechanisms of friend/foe discrimination involving major histocompatibility complex and similar proteins are analyzed in historical perspective—from bacteria to lower chordates.
机译:交配伴侣的“自身免疫测试”假说假设形成了一种基于免疫的个体感知系统,该系统涉及体内选择自身关键抗原或警报分子的正向或反向复制品。当出现新的适应时,这样的系统确保了信号系统和信号感知系统的协调变化,这在有限的世代内自动提供了生殖隔离。几乎所有活生物体中都有朋友/敌人识别系统,这表明在进化的最早阶段就对潜在的交配伴侣进行了自身免疫测试机制的形成。从历史的角度分析了从主要细菌相容性复合体和相似蛋白质中识别出友/敌的可能机制,从细菌到低等弦。

著录项

  • 来源
    《Biology Bulletin》 |2006年第4期|p.311-322|共12页
  • 作者

    A. V. Markov; A. M. Kulikov;

  • 作者单位

    Paleontological Institute, Russian Academy of Sciences, Profsoyuznaya ul. 123, Moscow, 117997 Russia;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 生物科学;
  • 关键词

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