• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Biology Bulletin >Apoptosis in P388 Leukemia Cells Induced by Specific Inhibitors of 5- and 12-Lipoxygenase and the Product of Cyclooxygenase, Prostaglandin E_2
【24h】

Apoptosis in P388 Leukemia Cells Induced by Specific Inhibitors of 5- and 12-Lipoxygenase and the Product of Cyclooxygenase, Prostaglandin E_2

机译：5-和12-脂氧合酶的特异性抑制剂和环氧合酶前列腺素E_2的产物诱导的P388白血病细胞凋亡

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

We studied the effect of specific inhibitors of 5- and 12-lipoxygenases as well as the product of cyclooxygenase activity, prostaglandin E_2, on proliferation and death of P388 leukemia cells. Inhibition of 5-and 12-lipoxygenases in the cells inhibits proliferation and induces apoptosis. The concentrations of baicalein, an inhibitor of 12-lipoxygenase, and AA861, an inhibitor of 5-lipoxygenase, causing a 50% death rate (LC_(50)) proved to be the same, 50 μM. Excessive prostaglandin also inhibited proliferation of the cells and induced apoptosis. The LC_(50) for prostaglandin E_2 was 4μM. The obtained data suggest that apoptosis in P388 cells after lipoxygenase inhibition can be induced by both deficiency of lipoxygenase products and excess of prostaglan-dins in the cell.
机译：我们研究了5-和12-脂氧合酶的特异性抑制剂以及环氧合酶活性产物前列腺素E_2对P388白血病细胞增殖和死亡的影响。细胞中5-和12-脂氧合酶的抑制作用抑制增殖并诱导细胞凋亡。证明黄causing素（一种12-脂氧合酶的抑制剂）和AA861（一种5-脂氧合酶的抑制剂）引起50％的死亡率（LC_（50））的浓度相同，为50μM。过量的前列腺素也抑制细胞增殖并诱导细胞凋亡。前列腺素E_2的LC_（50）为4μM。获得的数据表明，脂氧合酶产物的缺乏和细胞中过量的前列腺素均可诱导脂氧合酶抑制后的P388细胞凋亡。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号