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Anabolic Effect of Natural and Synthetic Antioxidants

机译：天然和合成抗氧化剂的合成代谢作用

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The order of responses of cell systems of organs and the changes in the content of some proteins in mouse and dog blood in response to addition of natural (α-tocopherol) and synthetic (ionol) antioxidants was studied at the whole-body level using ERP spectroscopy, radioisotope analysis, and chemiluminescence technique. Responses were evaluated by the temporary and concentration-dependent changes in the activity of ribo-nucleotide reductase and the rate of protein and DNA synthesis in organs of the mouse, as well as by the changes in the pools of Fe~(3+)-transfenin and Cu~(2+)-ceruloplasmin in blood and the antiradical activity of blood plasma of the dog and mouse. During the first 24 h of exposure to α-tocopherol, the activity ribonucleotide reductase in the bone marrow rapidly increased, whereas the activity of this enzyme and the rate of DNA synthesis in the thymus and spleen were suppressed by 30-50% compared to the control. The changes in these parameters had a phase mode with maxima on days 2-3 and 6-8. The stimulatory effect of the antioxidant on the processes of synthesis was concentration-dependent. We found that the optimal stimulation of the synthesis of deoxyribonu-cleotides, DNA, and protein was achieved by single administration of α-tocopherol at a dose of 20 mg per dog with an average weight of 15 kg and 17mg/kg in the case of mice. Single or repeated administration of higher doses of α-tocopherol was either ineffective or even suppressed the synthesis of DNA and deoxyribonucle-otides. Ionol administered at a dose of 60 mg/kg increased DNA and protein synthesis in mouse organs 2-4 and 1.2-1.5 times, respectively, compared to the control. It was also shown that single and repeated administration of α-tocopherol to dogs increased the pool of Fe~(3+)-transferrin and Cu~(2+)-ceruloplasmin in blood 2-3 times and by 20-30%, respectively, compared to the control. It is suggested to use changes in Fe~(3+)-transferrin pool in peripheral blood for evaluation of the stimulatory effect of antioxidants on the synthesis of macromolecules in organs and for the determination of dependence of this effect on the concentration of antioxidants.
机译：使用ERP在全身水平上研究了响应于天然（α-生育酚）和合成（紫罗兰）抗氧化剂的添加，小鼠和犬血中器官细胞系统的响应顺序以及某些蛋白质含量的变化。光谱学，放射性同位素分析和化学发光技术。通过小鼠核糖核苷酸还原酶活性的暂时和浓度依赖性变化以及小鼠器官中蛋白质和DNA合成速率以及Fe〜（3 +）-池中的变化来评估反应狗和小鼠血液中的transfenin和Cu〜（2 +）-ceruloplasmin和血浆的抗自由基活性。在暴露于α-生育酚的最初24小时内，骨髓中的核糖核苷酸还原酶活性迅速增加，而与之相比，该酶的活性以及胸腺和脾脏中DNA的合成率被抑制了30-50％。控制。这些参数的变化具有在2-3天和6-8天达到最大值的阶段模式。抗氧化剂对合成过程的刺激作用是浓度依赖性的。我们发现，通过以每只狗20 mg的剂量单次施用α-生育酚，可以最佳地刺激脱氧核糖核酸，DNA和蛋白质的合成，对于平均体重为15 kg和17mg / kg的狗。老鼠。单次或重复施用较高剂量的α-生育酚无效或什至抑制了DNA和脱氧核糖核酸的合成。与对照组相比，以60 mg / kg的剂量施用的紫罗兰分别可提高小鼠器官2-4和1.2-1.5倍的DNA和蛋白质合成。还表明，对狗进行单次或重复施用α-生育酚可增加血液中Fe〜（3 +）-转铁蛋白和Cu〜（2 +）-铜蓝蛋白的储量分别为2-3倍和20-30％ ，相比之下。建议利用外周血Fe〜（3 +）-转铁蛋白库的变化来评估抗氧化剂对器官中大分子合成的刺激作用，并确定这种作用对抗氧化剂浓度的依赖性。

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