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首页> 外文期刊>Biology Bulletin >Astaxanthin Has a Potential Role in Antioxidation and Oxidative Damage Repair in UVC Irradiated Mice
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Astaxanthin Has a Potential Role in Antioxidation and Oxidative Damage Repair in UVC Irradiated Mice

机译：虾青素在UVC辐照小鼠的抗氧化和氧化损伤修复中具有潜在作用

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摘要

The anti-oxidative activity and oxidative damage repair potential of dietary AS in UVC irradiated mice was studied in present study. The activities of superdismutase (SOD) and glutathione peroxidase (GPx) in the liver and serum of mice increased dramatically at treatment with a dose of 100 mg/kg bodyweight AS during 10 days UVC light irradiation in comparison with the control group. Concurrently, the gene expression levels of sod1, sod2, gpx1 and gpx2, as determined by real-time quantitative PCR, were also up-regulated in the liver in the AS treated group during the UVC irradiation. For further understanding the oxidative damage repair potential of dietary AS in UVC irradiated mice, after 7 days AS and VE treatment, the SOD and GPx activities also increased significantly in liver and serum in mice fed with AS compared to the UVC light treated group. The results obtained here strongly suggested that AS reduces the UVC irradiation oxidative stress dramatically in short time.
机译：研究了膳食AS对UVC辐照小鼠的抗氧化活性和氧化损伤修复潜力。与对照组相比，在10天的UVC光照射下，以100 mg / kg体重AS的剂量处理小鼠，肝脏和血清中的超歧化酶（SOD）和谷胱甘肽过氧化物酶（GPx）的活性显着增加。同时，通过实时定量PCR确定的sod1，sod2，gpx1和gpx2的基因表达水平在UVC照射期间在AS治疗组的肝脏中也被上调。为了进一步了解经UVC照射的小鼠饮食中AS的氧化损伤修复潜力，AS和VE治疗7天后，与UVC光照治疗组相比，接受AS喂养的小鼠肝脏和血清中的SOD和GPx活性也显着增加。此处获得的结果强烈表明，AS可在短时间内显着降低UVC辐射的氧化应激。

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