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首页> 外文会议>International Conference on Machinery, Materials and Computing Technology >Effects of pine bark procyanidins extract on blood glucose, blood lipid and antioxidation in diabetic mice
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Effects of pine bark procyanidins extract on blood glucose, blood lipid and antioxidation in diabetic mice

机译：松树树皮原霉素提取物对糖尿病小鼠血糖，血脂和抗氧化的影响

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Objective: To study the effects of pine bark procyanidins extract on blood glucose, blood lipid and antioxidation in diabetic mice. Methods: Diabetic mice model was made by intraperitoneal injection of Streptozotocin (STZ). Diabetic mouse were randomly divided into model group, Metformin group (250mg/kg), pine bark procyanidins extract high-dose group (400mg/kg), middle-dose group (200mg/kg) and low-dose group (100mg/kg). Fasting blood glucose was measured after continuous intragastric administration 8 weeks. Blood samples were taken out from the tail of diabetic mice to measure fasting blood glucose; Then blood samples were taken out from the eyeball to measure the serum activity of superoxide dismutase (SOD), INS content, MDA content and blood lipid level. Results: Pine bark procyanidins extract high and middle-dose group can significantly lower the blood glucose level in STZ induced diabetic mice; Serum INS content in pine bark procyanidins extract high-dose group was higher than the model group significantly (p<0.05); Serum SOD content in pine bark procyanidins extract high and middle-dose group was higher than the model group significantly (p<0.05); Serum MDA content in pine bark procyanidins extract high-dose group was lower than the model group significantly (p<0.05); TG, TC in pine bark procyanidins extract middle-dose group and LDL-C content in pine bark procyanidins extract high-dose group were lower than the model group significantly (p<0.05); HDL-C content in pine bark procyanidins extract high-dose group was higher than the model group significantly (p<0.05). Conclusion: The pine bark procyanidins extract had a significant effects on reducing blood glucose, antioxidation and improving blood lipid level in STZ induced diabetic mice.
机译：目的：探讨松树皮胰岛素提取物对糖尿病小鼠血糖，血脂和抗氧化的影响。方法：糖尿病小鼠模型是通过腹腔注射链脲佐菌素（STZ）进行的。糖尿病小鼠随机分为模型组，二甲双胍组（250mg / kg），松树鳞片原霉素提取高剂量组（400mg / kg），中剂量组（200mg / kg）和低剂量组（100mg / kg） 。连续胃内给药8周后测量空腹血糖。从糖尿病小鼠的尾部取出血液样品以测量空腹血糖;然后从眼球中取出血液样品，以测量超氧化物歧化酶（SOD），INS含量，MDA含量和血脂水平的血清活性。结果：松树树皮原因西氨酸提取物高和中剂量组可显着降低STZ诱导糖尿病小鼠的血糖水平;松树树皮胰岛胺提取物高剂量组的血清INS含量显着高于模型组（P <0.05）;血清吠谷糖苷提取高和中剂量组的血清SOD含量显着高于模型组（P <0.05）;松树树皮原霉素提取物高剂量组的血清MDA含量显着低于模型组（P <0.05）; TG，TC在松树树皮胰岛蛋白提取中剂量组和松树树皮胰岛蛋白的LDL-C含量提取高剂量组显着较低（P <0.05）;松树树皮原霉素中的HDL-C含量提取高剂量组显着高于模型组（P <0.05）。结论：松树树皮原霉素提取物对减少血糖，抗氧化和改善STZ诱导糖尿病小鼠的血脂水平具有显着影响。

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