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首页> 外文期刊>Biology Bulletin >The Study of Cognitive-Stimulating Activity of Fluorinated Tetrahydrocarbazole Derivatives and Behavioral Responses in Transgenic Tg6799 Mice with Alzheimer's Disease
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The Study of Cognitive-Stimulating Activity of Fluorinated Tetrahydrocarbazole Derivatives and Behavioral Responses in Transgenic Tg6799 Mice with Alzheimer's Disease

机译：转基因TG6799小鼠氟化四氢咔唑衍生物的认知刺激活性与阿尔茨海默氏病

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摘要

The cognitive-stimulating, neuroprotective effects of promising fluorinated tetrahydrocarbazole derivatives (CA-7043x and CA-7050x) on the hippocampus-dependent memory of outbred mice (CD1) and transgenic Tg6799 mice, as well as their effect on anxiety, locomotor activity, and orienting-exploratory behavior of animals, were studied. It was found that both compounds have a pronounced cognitive-stimulating effect on CD1 mice, but do not show neuroprotective effects on memory support in Tg6799 mice. It is noted that, in the open-field test, the CA-7050x compound has a positive effect on the orientating behavior, and the CA-7043x compound has a positive effect on the exploratory response in the nontransgenic control.
机译：对氟化四氢咔唑衍生物（Ca-7043x和Ca-7050x）对异鼠依赖性小鼠（CD1）和转基因TG6799小鼠的影响，以及它们对焦虑，运动活动的影响，以及它们对焦虑，运动活动的影响研究了动物的探索行为。发现两种化合物对CD1小鼠具有明显的认知刺激作用，但对TG6799小鼠中的记忆载体没有显示出神经保护作用。注意，在开场试验中，Ca-7050x化合物对取向行为具有阳性作用，Ca-7043x化合物对非转基因对照中的探索性反应具有积极影响。

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  • 来源
    《Biology Bulletin》 |2019年第3期|268-276|共9页
  • 作者

    Nikolaeva N. S.; Maltsev A. V.; Ovchinnikov R. K.; Sokolov V. B.; Aksinenko A. Yu.; Bovina E. V.; Kinzirsky A. S.;

  • 作者单位

    Russian Acad Sci Inst Physiol Act Cpds Chernogolovka 142432 Moscow Oblast Russia;

    Russian Acad Sci Inst Physiol Act Cpds Chernogolovka 142432 Moscow Oblast Russia;

    Russian Acad Sci Inst Physiol Act Cpds Chernogolovka 142432 Moscow Oblast Russia;

    Russian Acad Sci Inst Physiol Act Cpds Chernogolovka 142432 Moscow Oblast Russia;

    Russian Acad Sci Inst Physiol Act Cpds Chernogolovka 142432 Moscow Oblast Russia;

    Russian Acad Sci Inst Physiol Act Cpds Chernogolovka 142432 Moscow Oblast Russia;

    Russian Acad Sci Inst Physiol Act Cpds Chernogolovka 142432 Moscow Oblast Russia;

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