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首页> 外文期刊>Biomarkers >Serum RBP4 positively correlates with triglyceride level but not with BMI, fat mass and insulin resistance in healthy obese and non-obese individuals
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Serum RBP4 positively correlates with triglyceride level but not with BMI, fat mass and insulin resistance in healthy obese and non-obese individuals

机译：健康肥胖者和非肥胖者的血清RBP4与甘油三酯水平呈正相关，与BMI，脂肪量和胰岛素抵抗无关

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Purpose: Retinol binding protein 4 (RBP4) has recently been identified as an adipokine possibly involved in the development of impaired glucose metabolism. We aimed to test serum RBP4 in healthy non-obese individuals and in patients with well-characterized phenotype: obesity without confounding effects of diabetes, metabolic syndrome or dyslipidaemia. Additionally, we examined whether serum RBP4 is associated with anthropometric parameters, insulin resistance and blood lipid parameters.Patients and methods: Twenty-eight patients with obesity and no co-morbidities and twenty-five age-matched lean controls were recruited. Anthropometric parameters, body composition, fasting blood lipid profile, RBP4, glucose and insulin were assessed and HOMA-IR was calculated.Results: Mean concentration of RBP4 did not differ between studied groups (in obese patients was 33.9 +/- 34.46 mu g/ml and 32.53 +/- 2.53 mu g/ml in non-obese controls). RBP4 positively correlated with serum triglycerides in obese and non-obese individuals (r = 0.74, p = 0.03 and r = 0.62, p = 0.02, respectively) and did not show any significant associations with HOMA-IR, anthropometric and body composition parameters.Conclusions: Excessive adiposity without co-morbidities is not associated with higher levels of circulating RBP4. Serum RBP4 cannot be considered as a direct predictive marker for impaired glucose metabolism. RBP4 possibly contributes to lipid metabolism.
机译：目的：视黄醇结合蛋白4（RBP4）最近被鉴定为可能与葡萄糖代谢受损的发展有关的脂肪因子。我们的目的是在健康的非肥胖个体和特征明确的表型患者中测试血清RBP4：肥胖症，且不会混淆糖尿病，代谢综合征或血脂异常的影响。此外，我们检查了血清RBP4是否与人体测量学参数，胰岛素抵抗和血脂参数相关。患者和方法：招募了28例肥胖且无合并症的患者，并选择了25个与年龄匹配的瘦身对照。评估人体测量学参数，人体成分，空腹血脂，RBP4，葡萄糖和胰岛素并计算HOMA-IR。结果：研究组之间RBP4的平均浓度无差异（肥胖患者为33.9 +/- 34.46μg /毫升和非肥胖对照中的32.53 +/- 2.53毫克/毫升）。在肥胖和非肥胖个体中，RBP4与血清甘油三酯呈正相关（分别为r = 0.74，p = 0.03和r = 0.62，p = 0.02），并且与HOMA-IR，人体测量学和身体成分参数没有显着相关性。结论：没有合并症的肥胖过多与循环中的RBP4水平升高无关。血清RBP4不能被视为葡萄糖代谢受损的直接预测指标。 RBP4可能有助于脂质代谢。

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