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首页> 外文期刊>Biomarkers >p21, p53, TP53BP1 and p73 polymorphisms and the risk of gastric cardia adenocarcinoma in a Chinese population
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p21, p53, TP53BP1 and p73 polymorphisms and the risk of gastric cardia adenocarcinoma in a Chinese population

机译：p21，p53，TP53BP1和p73基因多态性与中国人群胃card门腺癌的风险

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摘要

Gastric cardia adenocarcinoma (GCA) is one of the most common malignant tumors and among the leading causes of cancer-related death. Genetic factors might play an important role in GCA carcinogenesis. Here, we performed a hospital-based case-control study to evaluate the effect of functional p21, p53, TP53BP1 and p73 single nucleotide polymorphisms (SNPs) on the risk of GCA. The study included 330 GCA cases and 608 controls. Genotypes were determined using the ligation detection reaction (LDR) method. The p21 rs1059234 TT, p21 rs3176352 GC/CC, p21 rs762623 GA and TP53BP1 rs560191 CC genotypes were associated with the risk of GCA, and a genotype combination effect was observed. After Bonferroni correction, the association remained significant for TP53BP1 rs560191 G>C, whereas the remaining four SNPs showed no association between the polymorphisms and GCA risk in all comparison models. Further large replication studies are needed to confirm the present findings.
机译：胃card门腺癌（GCA）是最常见的恶性肿瘤之一，也是与癌症相关的死亡的主要原因。遗传因素可能在GCA癌变中起重要作用。在这里，我们进行了一项基于医院的病例对照研究，以评估功能性p21，p53，TP53BP1和p73单核苷酸多态性（SNP）对GCA风险的影响。该研究包括330例GCA病例和608例对照。使用连接检测反应（LDR）方法确定基因型。 p21 rs1059234 TT，p21 rs3176352 GC / CC，p21 rs762623 GA和TP53BP1 rs560191 CC基因型与GCA风险相关，并观察到基因型组合效应。在Bonferroni校正后，对于TP53BP1 rs560191 G> C而言，该关联仍显着，而在所有比较模型中，其余四个SNP均未显示出多态性与GCA风险之间的关联。需要进一步的大型复制研究以证实目前的发现。

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  • 来源
    《Biomarkers》 |2015年第8期|109-115|共7页
  • 作者

    Shao Aizhong; Zheng Liang; Chen Suocheng; Gu Haiyong; Jing Hua;

  • 作者单位

    Nanjing Univ, Sch Med, Nanjing 210002, Jiangsu, Peoples R China|Nanjing Univ, Sch Clin Med, Dept Cardiothorac Surg, Jinling Hosp, Nanjing 210002, Jiangsu, Peoples R China|Jiangsu Univ, Affiliated Peoples Hosp, Dept Cardiothorac Surg, Zhenjiang, Peoples R China;

    Suzhou Univ, Dept Cardiothorac Surg, Peoples Hosp Changzhou 1, Changzhou, Peoples R China|Suzhou Univ, Affiliated Hosp 3, Changzhou, Peoples R China;

    Jiangsu Univ, Affiliated Peoples Hosp, Dept Cardiothorac Surg, Zhenjiang, Peoples R China;

    Jiangsu Univ, Affiliated Peoples Hosp, Dept Cardiothorac Surg, Zhenjiang, Peoples R China;

    Nanjing Univ, Sch Med, Nanjing 210002, Jiangsu, Peoples R China|Nanjing Univ, Sch Clin Med, Dept Cardiothorac Surg, Jinling Hosp, Nanjing 210002, Jiangsu, Peoples R China;

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  • 正文语种 eng
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  • 关键词

    Gastric cardia adenocarcinoma; molecular epidemiology; p21; p53; p73; polymorphisms; TP53BP1;

    机译：胃card门腺癌;分子流行病学;p21;p53;p73;多态性;TP53BP1;

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