Genetic polymorphism of pharmacogenomic VIP variants in the Deng people from the Himalayas in Southeast Tibet

Shi Xugang; Wang Li; Du Shuli; Wang Huijuan; Feng Tian; Jin Tianbo; Kang Longli

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Genetic polymorphism of pharmacogenomic VIP variants in the Deng people from the Himalayas in Southeast Tibet

机译：藏东南喜马拉雅山邓族药物基因组VIP变异的遗传多态性

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Little is known about polymorphic distribution of pharmacogenes among ethnicities, including the Deng people. In this study, we recruited 100 unrelated, healthy Deng people and genotyped them with respect to 76 different single-nucleotide polymorphisms by the PharmGKB database. Our results first indicated that the polymorphic distribution of pharmacogenes of the Deng people is most similar to CHD, suggesting that Deng people have a closest genetic relationship with CHD. Our data will enrich the database of pharmacogenomics and provide a theoretical basis for safer drug administration and individualized treatment plans, promoting the development of personalized medicine.

机译：人们对包括邓族在内的种族之间的药理基因多态分布了解甚少。在这项研究中，我们招募了100名不相关的健康的邓族人，并通过PharmGKB数据库针对76种不同的单核苷酸多态性对他们进行了基因分型。我们的结果首先表明，邓氏人群药理基因的多态性分布与冠心病最为相似，这表明邓氏人群与冠心病的遗传关系最为密切。我们的数据将丰富药物基因组学数据库，并为更安全的药物管理和个性化治疗计划提供理论基础，从而促进个性化药物的发展。

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来源
《Biomarkers》 |2015年第8期|275-286|共12页
作者
Shi Xugang; Wang Li; Du Shuli; Wang Huijuan; Feng Tian; Jin Tianbo; Kang Longli;
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作者单位

Xizang Minzu Univ, Sch Med, Key Lab High Altitude Environm & Genes Related Di, Xianyang 712082, Shaanxi, Peoples R China|Xizang Minzu Univ, Sch Med, Key Lab Mol Genet Mech & Intervent Res High Altit, Xianyang 712082, Shaanxi, Peoples R China;

Xizang Minzu Univ, Sch Med, Key Lab High Altitude Environm & Genes Related Di, Xianyang 712082, Shaanxi, Peoples R China|Xizang Minzu Univ, Sch Med, Key Lab Mol Genet Mech & Intervent Res High Altit, Xianyang 712082, Shaanxi, Peoples R China;

NW Univ Xian, Sch Life Sci, Xian 710069, Shaanxi, Peoples R China;

NW Univ Xian, Sch Life Sci, Xian 710069, Shaanxi, Peoples R China|Natl Engn Res Ctr Miniaturized Detect Syst, Xian, Shaanxi, Peoples R China;

Natl Engn Res Ctr Miniaturized Detect Syst, Xian, Shaanxi, Peoples R China;

Xizang Minzu Univ, Sch Med, Key Lab High Altitude Environm & Genes Related Di, Xianyang 712082, Shaanxi, Peoples R China|Xizang Minzu Univ, Sch Med, Key Lab Mol Genet Mech & Intervent Res High Altit, Xianyang 712082, Shaanxi, Peoples R China|NW Univ Xian, Sch Life Sci, Xian 710069, Shaanxi, Peoples R China|Natl Engn Res Ctr Miniaturized Detect Syst, Xian, Shaanxi, Peoples R China;

Xizang Minzu Univ, Sch Med, Key Lab High Altitude Environm & Genes Related Di, Xianyang 712082, Shaanxi, Peoples R China|Xizang Minzu Univ, Sch Med, Key Lab Mol Genet Mech & Intervent Res High Altit, Xianyang 712082, Shaanxi, Peoples R China;

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正文语种 eng
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关键词
Genetic polymorphisms; pharmacogenomics; the Deng people; VIP variant;

机译：遗传多态性;药物基因组学;邓氏人;VIP变异体;

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1. Genetic structures of the Tibetans and the Deng people in the Himalayas viewed from autosomal STRs. [J] . Kang L, Li S, Gupta S, Journal of human genetics . 2010,第5期

机译：从常染色体STRs观察喜马拉雅地区藏族和邓族的遗传结构。
2. Genetic polymorphisms of pharmacogenomic VIP variants in the Dai population from Yunnan province [J] . Yujing Cheng, Run Dai, Wanlu Chen, Molecular Genetics & Genomic Medicine . 2020,第7期

机译：云南省傣族人口中药物VIP变异的遗传多态性
3. Genetic Polymorphisms of Pharmacogenomic VIP Variants in the Circassian Subpopulation from Jordan [J] . Laith N. AL-Eitan, Namarg N. Mohammad, Haneen W. Al-Maqableh, Current drug metabolism . 2019,第8期

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5. Novel Discovery and Functional Characterization of Key Genetic Variants that Influence the Pharmacogenomics of Anti-Platelet Therapy. [D] . Backman, Joshua D. 2016

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Genetic polymorphism of pharmacogenomic VIP variants in the Deng people from the Himalayas in Southeast Tibet

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