Switching from usual brand cigarettes to a tobacco-heating cigarette or snus: Part 1. Study design and methodology

Ogden Michael W.; Marano Kristin M.; Jones Bobbette A.; Stiles Mitchell F.

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Switching from usual brand cigarettes to a tobacco-heating cigarette or snus: Part 1. Study design and methodology

机译：从普通品牌的卷烟转换为热烟卷烟或鼻烟：第1部分。研究设计和方法

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A randomized, multi-center study was conducted to assess potential improvement in health status measures, as well as changes in biomarkers of tobacco exposure and biomarkers of biological effect, in current adult cigarette smokers switched to tobacco-heating cigarettes, snus or ultra-low machine yield tobacco-burning cigarettes (50/group) evaluated over 24 weeks. Study design, conduct and methodology are presented here along with subjects' disposition, characteristics, compliance and safety results. This design and methodology, evaluating generally healthy adult smokers over a relatively short duration, proved feasible. Findings from this randomized study provide generalized knowledge of the risk continuum among various tobacco products (ClinicalTrials.gov Identifier: NCT02061917).

机译：进行了一项随机，多中心研究，以评估在当前成年吸烟者改用热烟，低鼻烟或超低烟的成年吸烟者中，健康状况指标的潜在改善以及烟草暴露生物标志物和生物效应生物标志物的变化。在24周内评估了机器燃烧烟丝的香烟（50只/组）。本文介绍了研究设计，行为和方法，以及受试者的性格，特征，依从性和安全性结果。这种设计和方法论在较短的时间内对一般健康的成年吸烟者进行了评估，证明是可行的。这项随机研究的结果提供了各种烟草产品之间风险连续性的一般知识（ClinicalTrials.gov标识符：NCT02061917）。

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来源
《Biomarkers》 |2015年第8期|382-390|共9页
作者
Ogden Michael W.; Marano Kristin M.; Jones Bobbette A.; Stiles Mitchell F.;
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作者单位

RAI Serv Co, Winston Salem, NC 27102 USA;

RAI Serv Co, Winston Salem, NC 27102 USA;

RJ Reynolds Tobacco Co, Winston Salem, NC USA;

RJ Reynolds Tobacco Co, Winston Salem, NC USA;

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正文语种 eng
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关键词
Biomarkers; compliance; feasibility; health status measures; multi-center randomized study; risk continuum;

机译：生物标志物;合规性;可行性;健康状况测量;多中心随机研究;风险连续性;

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1. Switching from usual brand cigarettes to a tobacco-heating cigarette or snus: Part 2. Biomarkers of exposure [J] . Ogden Michael W., Marano Kristin M., Jones Bobbette A., Biomarkers . 2015,第1a8期

机译：从普通品牌的卷烟转变为热烟卷烟或鼻烟：第2部分。暴露的生物标志物
2. Switching from usual brand cigarettes to a tobacco-heating cigarette or snus: Part 3. Biomarkers of biological effect [J] . Ogden Michael W., Marano Kristin M., Jones Bobbette A., Biomarkers . 2015,第1a8期

机译：从普通品牌香烟转换为加热烟草的香烟或鼻烟：第3部分。具有生物效应的生物标志物
3. Brand switching or reduced consumption? A study of how cigarette taxes affect tobacco consumption [J] . Chen Chiang-Ming, Chang Kuo-Liang, Lin Lin, The European journal of health economics: HEPAC : health economics in prevention and care . 2014,第9期

机译：品牌转换还是减少消费？关于卷烟税如何影响烟草消费的研究
4. QUANTIFYING THE AMOUNT OF CIGARETTE SMOKE GENERATED FROM POPULAR BRANDS OF CIGARETTES TO HELP ESTIMATE RISK AND EXPOSURE TO COMPONENTS OF SECOND-HAND SMOKE [C] . AJ Chibbaro, GA Chibbaro Indoor Air 2005 . 2005

机译：量化从流行品牌的香烟中产生的香烟烟雾的量，以帮助估计风险和暴露于二次烟雾的成分
5. Changes in reported tar yields and cigarette design in samples of Chinese cigarettes, 2009-2012. [D] . Schneller, Liane Margaret. 2014

机译：2009-2012年中国卷烟样本中报告的焦油产率和卷烟设计的变化。
6. Switching from usual brand cigarettes to a tobacco-heating cigarette or snus: Part 3. Biomarkers of biological effect [O] . Michael W. Ogden, Kristin M. Marano, Bobbette A. Jones, -1

机译：从普通品牌香烟转换为加热烟草的香烟或鼻烟：第3部分。具有生物效应的生物标志物
7. Switching from usual brand cigarettes to a tobacco-heating cigarette or snus: Part 1. Study design and methodology [O] . Michael W. Ogden, Kristin M. Marano, Bobbette A. Jones, 2015

机译：从通常的品牌卷烟切换到烟草加热烟或鼻烟：第1.研究设计和方法

Switching from usual brand cigarettes to a tobacco-heating cigarette or snus: Part 1. Study design and methodology

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