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首页> 外文期刊>Biomarkers >Combining serum and urine biomarkers in the early diagnosis of mild cognitive impairment that evolves into Alzheimer's disease in patients with the apolipoprotein E epsilon 4 genotype
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Combining serum and urine biomarkers in the early diagnosis of mild cognitive impairment that evolves into Alzheimer's disease in patients with the apolipoprotein E epsilon 4 genotype

机译：结合血清和尿液生物标志物对载脂蛋白E epsilon 4基因型患者发展为阿尔茨海默氏病的轻度认知障碍的早期诊断

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摘要

Possession of the apolipoprotein E (APOE) epsilon 4 genotype is a major predictor of progression to Alzheimer's disease (AD), particularly in patients with mild cognitive impairment (MCI). However, the use of APOE genotyping in the diagnosis of MCI is limited due to its low sensitivity and specificity, which often results in a high false-positive rate. In this study, we found that there was a significant decrease in serum BDNF and notable increase in urine AD7c-NTP in MCI patients who harbored the APOE e4 allele. Both serum BDNF and urine AD7c-NTP had higher positive predictive values and were more sensitive biomarkers of MCI. Additionally, a testing strategy employing serum BDNF and urine AD7c-NTP revealed increases in sensitivity, positive and negative predictive values, and predictive ability compared with the use of either biomarker alone, suggested that combinatorial detection might have great potential for translation to the clinic.
机译：载脂蛋白E（APOE）epsilon 4基因型的拥有是进展为阿尔茨海默氏病（AD）的主要预测指标，尤其是在轻度认知障碍（MCI）患者中。但是，由于APOE基因分型在MCI诊断中的应用受到限制，因为其敏感性和特异性低，这通常会导致假阳性率较高。在这项研究中，我们发现携带APOE e4等位基因的MCI患者血清BDNF显着降低，尿AD7c-NTP显着增加。血清BDNF和尿液AD7c-NTP均具有较高的阳性预测值，并且是MCI的较敏感生物标志物。此外，采用血清BDNF和尿液AD7c-NTP的测试策略显示，与单独使用任何一种生物标志物相比，敏感性，阳性和阴性预测值以及预测能力均提高，这表明组合检测可能具有很大的潜力可用于临床翻译。

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  • 来源
    《Biomarkers》 |2015年第8期|84-88|共5页
  • 作者

    Wang Chao; Cui Yongjian; Yang Jingci; Zhang Jinrong; Yuan Dongcai; Wei Yan; Li Yumei; Duo Yali; Li Shengjun; Zhu Wenyi; Zheng Lei;

  • 作者单位

    Hebei Gen Hosp, Geriatr Key Lab, Shijiazhuang, Hebei, Peoples R China;

    Harrison Int Peace Hosp, Dept Neurol, Hengshui, Hebei, Peoples R China;

    Hebei Med Univ, Hosp 2, Dept Hematol, Shijiazhuang, Hebei, Peoples R China;

    Harrison Int Peace Hosp, Cent Lab, Hengshui 053000, Hebei, Peoples R China;

    Harrison Int Peace Hosp, Dept Neurol, Hengshui, Hebei, Peoples R China;

    Harrison Int Peace Hosp, Dept Neurol, Hengshui, Hebei, Peoples R China;

    Harrison Int Peace Hosp, Dept Neurol, Hengshui, Hebei, Peoples R China;

    Harrison Int Peace Hosp, Cent Lab, Hengshui 053000, Hebei, Peoples R China;

    Harrison Int Peace Hosp, Cent Lab, Hengshui 053000, Hebei, Peoples R China;

    Harrison Int Peace Hosp, Cent Lab, Hengshui 053000, Hebei, Peoples R China;

    Harrison Int Peace Hosp, Cent Lab, Hengshui 053000, Hebei, Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
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  • 关键词

    Alzheimer's disease; apolipoprotein E epsilon 4; mild cognitive impairment; serum BDNF; urine AD7c-NTP;

    机译：阿尔茨海默氏病;载脂蛋白Eε4;轻度认知障碍;血清BDNF;尿液AD7c-NTP;

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