Promoter hypermethylation of BCL6B gene is a potential plasma DNA biomarker for gastric cancer

Yang Qingfan; Gao Jing; Xu Lixia; Zeng Zhirong; Sung Joseph J. Y.; Yu Jun

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Promoter hypermethylation of BCL6B gene is a potential plasma DNA biomarker for gastric cancer

机译：BCL6B基因启动子高甲基化是胃癌潜在的血浆DNA生物标志物

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We previously showed that BCL6B acts as a tumor suppressor in gastric cancer and up to 66% gastric cancer patients have promoter hypermethylation in tumor tissues. We aimed to evaluate the feasibility of detecting BCL6B methylation in plasma DNA as a potential biomarker for gastric cancer. Hypermethylation of the CpG islands in BCL6B promoter was detected in 42.5% (17/40) plasma DNA samples from gastric cancer patients, while no methylation was found in the plasma DNA of healthy controls (p<0.001). BCL6B methylation may serve as a novel potential non-invasive plasma biomarker for the detection of gastric cancer.

机译：我们以前显示BCL6B在胃癌中起着抑癌作用，并且高达66％的胃癌患者在肿瘤组织中具有启动子高甲基化。我们旨在评估检测血浆DNA中BCL6B甲基化作为胃癌潜在生物标志物的可行性。在来自胃癌患者的42.5％（17/40）血浆DNA样品中检测到BCL6B启动子中CpG岛的超甲基化，而在健康对照组的血浆DNA中未发现甲基化（p <0.001）。 BCL6B甲基化可以作为一种新型的潜在非侵入性血浆生物标志物，用于检测胃癌。

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来源
《Biomarkers》 |2013年第8期|721-725|共5页
作者
Yang Qingfan; Gao Jing; Xu Lixia; Zeng Zhirong; Sung Joseph J. Y.; Yu Jun;
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作者单位

Chinese Univ Hong Kong, Inst Digest Dis, Shatin, Hong Kong, Peoples R China|Chinese Univ Hong Kong, Dept Med & Therapeut, Shatin, Hong Kong, Peoples R China|Chinese Univ Hong Kong, Li Ka Shing Inst Hlth Sci, State Key Lab Digest Dis, Shatin, Hong Kong, Peoples R China|Chinese Univ Hong Kong, Shenzhen Res Inst, Shenzhen, Peoples R China|Sun Yat Sen Univ, Affiliated Hosp 1, Dept Gastroenterol, Guangzhou 510275, Guangdong, Peoples R China;

Peking Univ, Canc Hosp & Inst, Dept Gastrointestinal Oncol, Minist Educ,Key Lab Carcinogenesis & Translat Res, Beijing 100871, Peoples R China;

Chinese Univ Hong Kong, Inst Digest Dis, Shatin, Hong Kong, Peoples R China|Chinese Univ Hong Kong, Dept Med & Therapeut, Shatin, Hong Kong, Peoples R China|Chinese Univ Hong Kong, Li Ka Shing Inst Hlth Sci, State Key Lab Digest Dis, Shatin, Hong Kong, Peoples R China|Chinese Univ Hong Kong, Shenzhen Res Inst, Shenzhen, Peoples R China;

Sun Yat Sen Univ, Affiliated Hosp 1, Dept Gastroenterol, Guangzhou 510275, Guangdong, Peoples R China;

Chinese Univ Hong Kong, Inst Digest Dis, Shatin, Hong Kong, Peoples R China|Chinese Univ Hong Kong, Dept Med & Therapeut, Shatin, Hong Kong, Peoples R China|Chinese Univ Hong Kong, Li Ka Shing Inst Hlth Sci, State Key Lab Digest Dis, Shatin, Hong Kong, Peoples R China|Chinese Univ Hong Kong, Shenzhen Res Inst, Shenzhen, Peoples R China;

Chinese Univ Hong Kong, Inst Digest Dis, Shatin, Hong Kong, Peoples R China|Chinese Univ Hong Kong, Dept Med & Therapeut, Shatin, Hong Kong, Peoples R China|Chinese Univ Hong Kong, Li Ka Shing Inst Hlth Sci, State Key Lab Digest Dis, Shatin, Hong Kong, Peoples R China|Chinese Univ Hong Kong, Shenzhen Res Inst, Shenzhen, Peoples R China;

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正文语种 eng
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关键词
BCL6B; biomarker; gastric cancer; plasma DNA; promoter methylation;

机译：BCL6B;生物标志物;胃癌;血浆DNA;启动子甲基化;

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6. Zic1 Promoter Hypermethylation in Plasma DNA Is a Potential Biomarker for Gastric Cancer and Intraepithelial Neoplasia [O] . Xueqin Chen, Zhenghua Lin, Meng Xue, -1

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Promoter hypermethylation of BCL6B gene is a potential plasma DNA biomarker for gastric cancer

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