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首页> 外文期刊>Biomarkers >Urinary p-cresol is elevated in small children with severe autism spectrum disorder
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Urinary p-cresol is elevated in small children with severe autism spectrum disorder

机译:患有严重自闭症谱系障碍的幼儿尿中对甲酚含量升高

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摘要

Several studies have described in autistic patients an overgrowth of unusual gut bacterial strains, able to push the fermentation of tyrosine up to the formation of p-cresol. We compared levels of urinary p-cresol, measured by high-performance liquid chromatography-ultraviolet, in 59 matched case-control pairs. Urinary p-cresol was significantly elevated in autistic children smallerthan 8years of age (p < 0.01), typically females (p < 0.05), and more severely affected regardless of sex (p<0.05). Urinary cotinine measurements excluded smoking-related hydrocarbon contaminations as contributors to these differences. Hence, elevated urinary p-cresol may serve as a biomarker of autism liability in small children, especially females and more severely affected males.
机译:几项研究描述了自闭症患者中异常肠道细菌菌株的过度生长,这些菌株能够推动酪氨酸的发酵直至对甲酚的形成。我们在59个匹配的病例对照对中比较了通过高效液相色谱-紫外线测量的尿中对甲酚水平。在小于8岁的自闭症儿童中,尿中的对甲酚含量显着升高(p <0.01),通常是女性(p <0.05),并且无论性别如何,其影响都更为严重。尿中可替宁的测定排除了与吸烟有关的碳氢化合物污染,是造成这些差异的原因。因此,尿中对甲酚含量升高可作为幼儿,特别是女性和受影响较严重的男性中自闭症倾向的生物标志。

著录项

  • 来源
    《Biomarkers》 |2011年第3期|p.252-260|共9页
  • 作者单位

    Laboratory of Molecular Psychiatry and Neurogenetics, University Campus Bio-Medico, Rome, Italy,Department of Experimental Neurosciences, I.R.C.C.S. "Fondazione S. Lucia," Rome, Italy;

    Department of Experimental Neurosciences, I.R.C.C.S. "Fondazione S. Lucia," Rome, Italy,Department of Internal Medicine, University "Tor Vergata," Rome, Italy;

    Laboratory of Molecular Psychiatry and Neurogenetics, University Campus Bio-Medico, Rome, Italy,Department of Experimental Neurosciences, I.R.C.C.S. "Fondazione S. Lucia," Rome, Italy;

    Department of Child Neuropsychiatry, University "Tor Vergata," Rome, Italy;

    Department of Child Neuropsychiatry, University "Tor Vergata," Rome, Italy;

    Department of Child Neurology and Psychiatry, I.R.C.C.S. "Stella Marts" and University of Pisa, Pisa, Italy;

    Department of Child Neurology and Psychiatry, I.R.C.C.S. "Stella Marts" and University of Pisa, Pisa, Italy;

    Department of Pediatrics, University "Federico II," Naples, Italy;

    Department of Child Neuropsychiatry, University of Milan, Milan, Italy;

    Department of Child Neuropsychiatry, University of Milan, Milan, Italy;

    Department of Child Neuropsychiatry, University of Turin, Turin, Italy;

    Department of Child Neuropsychiatry, University of Turin, Turin, Italy;

    Department of Experimental Neurosciences, I.R.C.C.S. "Fondazione S. Lucia," Rome, Italy,Department of Internal Medicine, University "Tor Vergata," Rome, Italy;

    Laboratory of Molecular Psychiatry and Neurogenetics, University Campus Bio-Medico, Rome, Italy,Department of Experimental Neurosciences, I.R.C.C.S. "Fondazione S. Lucia," Rome, Italy;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    clostridium; cotinine; gut flora; organic contaminants; pervasive developmental disorders;

    机译:梭菌可替宁肠道菌群有机污染物;普遍性发育障碍;

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