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Serum levels of oncostatin M (a gp 130 cytokine): an inflammatory biomarker in periodontal disease

机译：血清抑癌素M（gp 130细胞因子）的水平：牙周疾病的炎症生物标志物

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摘要

Objective: Periodontitis is considered to be a risk factor for systemic diseases such as atherosclerosis, diabetes, etc., and cytokines play a key role. The present study was carried out to measure the level of serum oncostatin M (OSM) in patients with chronic periodontitis, and to evaluate the effect of non-surgical periodontal therapy on the serum OSM concentration.rnMaterials and methods: Sixty subjects were divided into three groups (each group n = 20) based on the gin-gival index (GI), probing pocket depth (PPD) and clinical attachment level (CAL): group Ⅰ healthy; group Ⅱ gingivitis; and group Ⅲ chronic periodontitis. Group III patients were followed for 8 weeks after non-surgical periodontal therapy as the after-treatment group (group IV). Estimation of serum OSM was done using an enzyme-linked immunosorbent assay.rnResults: The mean OSM concentrations in serum were highest in the chronic periodontitis group (mean 68.05 pg ml~(-1)) and decreased following treatment (39.65 pg ml~(-1)) while OSM was undetectable in healthy subjects or in patients with gingivitis.rnConclusion: Increased serum OSM concentration in patients with chronic periodontitis and its positive correlation with PPD and CAL, suggest its role as an inflammatory biomarker in periodontal disease and it may exaggerate other systemic conditions such as atherosclerosis and rheumatoid arthritis.
机译：目的：牙周炎被认为是动脉粥样硬化，糖尿病等全身性疾病的危险因素，细胞因子起着关键作用。本研究旨在测量慢性牙周炎患者的血清抑瘤素M（OSM）水平，并评估非手术性牙周治疗对血清OSM浓度的影响。材料与方法：60例受试者分为三类根据gin-gival指数（GI），探查囊袋深度（PPD）和临床依从水平（CAL）分为两组（每组n = 20）： Ⅱ组牙龈炎；和Ⅲ组慢性牙周炎。非手术牙周治疗后，对III组患者进行随访8周，作为治疗后组（IV组）。结果：慢性牙周炎组的平均OSM浓度最高（平均68.05 pg ml〜（-1）），而在治疗后下降（39.65 pg ml〜（-1））。 -1））在健康受试者或牙龈炎患者中无法检测到OSM。rn结论：慢性牙周炎患者的血清OSM浓度升高，并且与PPD和CAL呈正相关，提示其在牙周疾病中作为炎性生物标志物起作用，并且可能夸大其他系统性疾病，例如动脉粥样硬化和类风湿关节炎。

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  • 来源
    《Biomarkers》 |2010年第3期|P.277-282|共6页
  • 作者

    A.R. Pradeep; rnThorat Manojkumar S.; rnGarg Garima; rnArjun Raju;

  • 作者单位

    Department of Periodontics, Government Dental College and Research Institute, Bangalore-560002, Karnataka, India;

    rnDepartment of Periodontics, Government Dental College and Research Institute, Bangalore, Karnataka, India;

    rnDepartment of Periodontics, Government Dental College and Research Institute, Bangalore, Karnataka, India;

    Bangalore Medical College and Research Institute, Bangalore, Karnataka, India;

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  • 正文语种 eng
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  • 关键词

    oncostatin M; cytokines; serum; gingivitis; periodontitis; inflammatory biomarker;

    机译：抑素M;细胞因子血清;牙龈炎;牙周炎炎性生物标志物;

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