Synthesis and in vitro antitumoral activity of new 3,5-dicyanopyridine derivatives.

CoccoMT; CongiuC; LilliuV; OnnisV

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Synthesis and in vitro antitumoral activity of new 3,5-dicyanopyridine derivatives.

机译：新的3,5-二氰基吡啶衍生物的合成及体外抗肿瘤活性。

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A new series of 2-amino-4-aryl-6-dialkylamino-3,5-dicyanopyridines, 20-47, were synthesized in satisfactory overall yield, through a simple synthetic strategy using 3-amino-3-(dialkylamino)-propenenitriles 1 and 2 as key intermediates. 3,5-Dicyanopyridine derivatives 20-47 were evaluated for their in vitro anticancer activity toward cell lines of nine different types of human cancers. Some of the newly prepared compounds demonstrated inhibitory effects on the growth of a wide range of cancer cell lines generally at 10(-6) M level and in some cases at 10(-8) M concentration.

机译：通过使用3-氨基-3-（二烷基氨基）-丙烯腈的简单合成策略，以令人满意的总收率合成了一系列新的2-氨基-4-芳基-6-二烷基氨基-3,5-二氰基吡啶系列20-47。 1和2为关键中间体。评价了3，5-二氰基吡啶衍生物20-47对九种不同类型的人类癌症的细胞系的体外抗癌活性。一些新制备的化合物对多种癌细胞系的生长具有抑制作用，通常在10（-6）M的水平，在某些情况下在10（-8）M的浓度。

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来源
《Bioorganic and Medicinal Chemistry》 |2007年第4期|P.1859-1867|共9页
作者
CoccoMT; CongiuC; LilliuV; OnnisV;
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作者单位

Dipartimento di Tossicologia, Universita degli Studi di Cagliari, via Ospedale 72, Cagliari I-09124, Italy.;

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原文格式 PDF
正文语种 eng
中图分类药学;生物化学;
关键词
derivatives; In Vitro; Synthesis; strategy;

机译：衍生物;体外;合成;策略;

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1. Synthesis and in vitro antitumoral activity of new 3,5-dicyanopyridine derivatives. [J] . Cocco MT, Congiu C, Lilliu V, Bioorganic and medicinal chemistry . 2007,第4期

机译：新的3,5-二氰基吡啶衍生物的合成及体外抗肿瘤活性。
2. Synthesis and in vitro antitumoral activity of new 3,5-dicyanopyridine derivatives [J] . Maria T. Cocco, Cenzo Congiu, Valentina Lilliu, Bioorganic and Medicinal Chemistry . 2007,第4期

机译：新的3,5-二氰基吡啶衍生物的合成及体外抗肿瘤活性
3. Synthesis and in vitro antitumoral activity of new hydrazinopyrimidine-5-carbonitrile derivatives. [J] . Cocco MT, Congiu C, Lilliu V, Bioorganic and medicinal chemistry . 2006,第2期

机译：新型肼基嘧啶-5-腈衍生物的合成及体外抗肿瘤活性。
4. In Vitro Evaluation of Antitumoral Activity of Gemcitabine-loaded Liposomes in HumanThyroid Carcinoma Cells [C] . Maria Grazia Calvagno, Marilena Celano, Stefania Bulotta, Controlled Release Society annual meeting . 2004

机译：吉西他滨负载脂质体在人甲状腺癌细胞中的体外抗肿瘤活性评估
5. Synthesis of side chain-modified iodothyronines. Synthesis and structure-activity relationships (SARS) of galanthamine derivatives. Total synthesis of (+)-valyldetoxinine. Synthesis and mechanism of cyclic acetal and ketal formation in pentono-1,4-lactones. [D] . Han, So-Yeop. 1992

机译：侧链修饰的碘甲状腺素的合成。加兰他敏衍生物的合成及其构效关系（SARS）。（+）-Valyldetoxinine的全合成。戊通-1,4-内酯中环状缩醛和缩酮的合成及其机理。
6. Correction: Design, synthesis, crystal structure and fungicidal activity of (E)-5-(methoxyimino)-3,5-dihydrobenzo[e][1,2]oxazepin-4(1H)-one analogues [O] . Dongyan Yang, Chuan Wan, MengMeng He, 1924

机译：校正：（E）-5-（甲氧基亚氨基）-3,5-二氢苯并[e] [1,2]草氮杂-4（1H）-one类似物的设计，合成，晶体结构和杀真菌活性
7. Modifications on the Amino-3,5-dicyanopyridine Core To Obtain Multifaceted Adenosine Receptor Ligands with Antineuropathic Activity [O] . -1

机译：氨基-3,5-二氰基吡啶核的修饰，得到抗脉冲性活性的多型腺苷受体配体

Synthesis and in vitro antitumoral activity of new 3,5-dicyanopyridine derivatives.

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