Synthesis and antiproliferative activity of clausine E, mukonine, and koenoline bioisosteres

Francois Liger; Florence Popowycz; Thierry Besson; Laurent Picot; Carlos M. Galmarini; Benoit Joseph

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Synthesis and antiproliferative activity of clausine E, mukonine, and koenoline bioisosteres

机译：克劳斯碱E，鼠李糖碱和koenoline生物等排体的合成及其抗增殖活性

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摘要

Aza-analogues of clausine E, mukonine and koenoline were prepared from 1-(benzenesulfonyl)-1H-pyrrolo[2,3-b]pyridine -3-carboxaldehyde and their antiproliferative activity was evaluated against miscellaneous cancer cell lines and compared to those obtained with clausine E and mukonine.

机译：由1-（苯磺酰基）-1H-吡咯并[2,3-b]吡啶-3-羧甲醛制备克劳斯碱E，鼠李糖苷和koenoline的氮杂类似物，并评估其对其他癌细胞系的抗增殖活性，并与所得抗癌活性进行比较与克劳斯碱E和mukonine。

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来源
《Bioorganic and Medicinal Chemistry》 |2007年第16期|p.5615-5619|共5页
作者
Francois Liger; Florence Popowycz; Thierry Besson; Laurent Picot; Carlos M. Galmarini; Benoit Joseph;
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作者单位

Laboratoire de Chimie Organique 1, UMR - CNRS 5181, Universite Claude Bernard - Lyon 1, Batiment 308 - CPE, 43 Boulevard du 11 Novembre 1918, 69622 Villeurbanne Cedex, France;

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原文格式 PDF
正文语种 eng
中图分类药学;生物化学;
关键词
aza-carbazole; natural product; bioisostere; cancer;

机译：氮杂咔唑;天然产物;生物甾体;癌症;

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Synthesis and antiproliferative activity of clausine E, mukonine, and koenoline bioisosteres

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