Antitumor agents 243. Syntheses and cytotoxicity of desmosdumotin C derivatives.

Nakagawa Goto K; Wu JH; Bastow KF; Wu CC; Lee KH

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Antitumor agents 243. Syntheses and cytotoxicity of desmosdumotin C derivatives.

机译：抗肿瘤剂243.去粘链杜马汀C衍生物的合成和细胞毒性。

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摘要

New analogs of desmosdumotin C (1), in which other aromatic rings replaced the terminal phenyl group and the A-ring was modified, were synthesized. Compounds 2-9, 13, and 16 were evaluated in vitro against human tumor cell replication. The 4-bromophenyl analog (2) showed potent cytotoxic activity in four different tumor cell lines.

机译：合成了desmosdumotin C（1）的新类似物，其中其他芳香环取代了末端苯基，并对A环进行了修饰。在体外针对人肿瘤细胞复制评估了化合物2-9、13和16。 4-溴苯基类似物（2）在四种不同的肿瘤细胞系中显示出强大的细胞毒性活性。

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来源
《Bioorganic and Medicinal Chemistry》 |2005年第6期|P.2325-2330|共6页
作者
Nakagawa Goto K; Wu JH; Bastow KF; Wu CC; Lee KH;
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作者单位

Natural Products Laboratory, School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, USA.;

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原文格式 PDF
正文语种 eng
中图分类基础医学;
关键词
Carbon ion; Cytotoxicity; derivatives; analogs;

机译：碳离子;细胞毒性;衍生物;类似物;

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1. Antitumor agents. 284. new desmosdumotin B analogues with bicyclic B-ring as cytotoxic and antitubulin agents [J] . Nakagawa-Goto K., Wu P.-C., Lai C.-Y., Journal of Medicinal Chemistry . 2011,第5期

机译：抗肿瘤药。 284.具有双环B环的新的去铁链球菌素B类似物，作为细胞毒性和抗微管蛋白剂
2. Antitumor agents 259. Design, syntheses, and structure-activity relationship study of desmosdumotin C analogs [J] . Nakagawa-Goto K, Chen TH, Peng CY, Journal of Medicinal Chemistry . 2007,第14期

机译：抗肿瘤药259.去链杜马汀C类似物的设计，合成和构效关系研究
3. Antitumor agents 283. Further elaboration of desmosdumotin C analogs as potent antitumor agents: activation of spindle assembly checkpoint as possible mode of action. [J] . Nakagawa Goto K, Wu PC, Bastow KF, Bioorganic and medicinal chemistry . 2011,第5期

机译：抗肿瘤剂283.进一步修饰去链杜马汀C类似物作为有效的抗肿瘤剂：激活纺锤体装配检查点作为可能的作用方式。
4. Novel Angular Furoquinolinone Bearing Flexible Chain as Antitumor Agent: Design, Synthesis, Cytotoxic Evaluation and Studies on DNA-Binding [C] . The 12th Asian Pacific Confederation of Chemical Engineering Congress(第十二届亚太化工联盟大会暨化工展览会)论文集 . 2008

机译：新型角形呋喃喹啉酮具有柔性链作为抗肿瘤剂：设计，合成，细胞毒评价和DNA结合研究。
5. Syntheses and biological evaluation of polyamine/transition metal complexes as potential antitumor agents. [D] . Amunugama, Hemali Tennekone. 2007

机译：多胺/过渡金属配合物作为潜在抗肿瘤药物的合成及生物学评估。
6. Antitumor Agents 259. Design Syntheses and Structure-Activity-Relationship Study of Desmosdumotin C Analogs [O] . Kyoko Nakagawa-Goto, Tzu-Hsuan Chen, Chieh-Yu Peng, -1

机译：抗肿瘤剂259. Desmosdumotin C类似物的设计合成和结构活性关系研究
7. Antitumor Agents 259. Design, Syntheses, and Structure-Activity Relationship Study of Desmosdumotin C Analogs [O] . -1

机译：抗肿瘤剂259. Desmosdumotin C类似物的设计，合成和结构 - 活性关系
8. Studies on Syntheses of Amine-Carboxyboranes (Boron Analogues of Amino Acids) and Derivatives. [R] . Spielvogel, B. F., McPhail, A. T. 1987

机译：胺 - 羧基硼烷（氨基酸类似硼）及衍生物的合成研究。

Antitumor agents 243. Syntheses and cytotoxicity of desmosdumotin C derivatives.

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