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首页> 外文期刊>Biophysics >Use of EPR spectroscopy to check the changes in organism radioresistance. Experimental results
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Use of EPR spectroscopy to check the changes in organism radioresistance. Experimental results

机译：使用EPR光谱检查生物体抗辐射性的变化。实验结果

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摘要

The responses of dNTP, DNA, and protein synthesis systems in blood-forming organs of animals (dogs, mice) as well as changes in blood Fe3+-transferrin (Fe-TF) and Cu2+-ceruloplasmin (Cu-CP) pools upon γ-irradiation and administration of radioprotectors have been studied. It is shown that changes in Fe-TF and Cu-CP pools are indices of change in body radioresistance and are reliably checked by the EPR technique. An increase in the Fe-TF pool promotes the activation of synthesis of dNTP, DNA, and Fe3+-containing proteins, which are essential for repair efficiency during early postirradiation time as well as for the development of compensatory-restorative reactions of cellular systems; i.e., they are responsible for body resistance to DNA-damaging factors. It is important that the intensity of responses depends on the initial state of the organism. Thus, dogs with initial individual characteristics of blood typical of "depressed" or "activated" states had abnormally high responses to irradiation at low doses of 0.25 and 0.5 Gy. This fact is important for estimating the consequences of prolonged low-dose irradiation for the human population. It has been shown that radioprotectors efficient in the survival test activate the synthesis of dNTP, DNA, and proteins in organs. The intensity of dNTP synthesis and the time when dNTP pools become maximal determine the efficiency of protectors and the time of irradiation after their administration. [PUBLICATION ABSTRACT]
机译：dNTP，DNA和蛋白质合成系统在动物（狗，小鼠）的血液形成器官中的反应以及血液中Fe3 +-转铁蛋白（Fe-TF）和Cu2 +-铜蓝蛋白（Cu-CP）库在γ-已经研究了辐射防护剂的辐射和给药。结果表明，Fe-TF和Cu-CP池的变化是机体抗辐射性变化的指标，并通过EPR技术得到了可靠的检查。 Fe-TF池的增加促进了dNTP，DNA和含Fe3 +蛋白质合成的激活，这对于辐射后早期的修复效率以及细胞系统的补偿性修复反应的发展至关重要；即，它们负责机体对DNA破坏因子的抵抗力。重要的是，反应强度取决于生物体的初始状态。因此，具有典型的“抑郁”或“活化”状态的血液的初始个体特征的狗在0.25和0.5Gy的低剂量下对辐射具有异常高的响应。这个事实对于估计长期低剂量照射对人类的后果非常重要。已经表明，在存活试验中有效的放射防护剂激活了器官中dNTP，DNA和蛋白质的合成。 dNTP合成的强度和dNTP库达到最大的时间决定了保护剂的效率和给药后的照射时间。 [出版物摘要]

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