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首页> 外文期刊>Biophysics >Use of EPR Spectroscopy to Check the Changes in Organism Radioresistance. Experimental Results
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Use of EPR Spectroscopy to Check the Changes in Organism Radioresistance. Experimental Results

机译：使用EPR光谱检查生物辐射抗性的变化。实验结果

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The responses of dNTP, DNA, and protein synthesis systems in blood-forming organs of animals(dogs, mice) as well as changes in blood Fe~(3+)-transferrin (Fe-TF) and Cu~(2+)-ceruloplasmin Cu-CP) pools uponγ-irradiation and administration of radioprotectors have been studied. It is shown that changes in Fe-TF and Cu-CP pools are indices of change in body radioresistance and are reliably checked by the EPR technique. Anincrease in the Fe-TF pool promotes the activation of synthesis of dNTP, DNA, and Fe~(3+)-containing proteins,which are essential for repair efficiency during early postirradiation time as well as for the development of com-pensatory-restorative reactions of cellular systems; i.e., they are responsible for body resistance to DNA-dam-aging factors. It is important that the intensity of responses depends on the initial state of the organism. Thus,dogs with initial individual characteristics of blood typical of "depressed" or "activated" states had abnormallyhigh responses to irradiation at low doses of 0.25 and 0.5 Gy. This fact is important for estimating the conse-quences of prolonged low-dose irradiation for the human population. It has been shown that radioprotectorsefficient in the survival test activate the synthesis of dNTP, DNA, and proteins in organs. The intensity of dNTPsynthesis and the time when dNTP pools become maximal determine the efficiency of protectors and the timeof irradiation after their administration.
机译：动物（狗，小鼠）血液形成器官中dNTP，DNA和蛋白质合成系统的反应以及血液中Fe〜（3 +）-转铁蛋白（Fe-TF）和Cu〜（2 +）-的变化已经研究了γ-射线照射后的铜蓝蛋白Cu-CP）池和放射防护剂的施用。结果表明，Fe-TF和Cu-CP池的变化是机体抗辐射性变化的指标，并通过EPR技术得到了可靠的检查。 Fe-TF库的增加促进了dNTP，DNA和含Fe〜（3+）蛋白质的合成的激活，这对于辐射后早期的修复效率以及对补体修复的发展必不可少细胞系统的反应;即，它们负责机体对DNA损伤老化因子的抵抗力。重要的是，反应强度取决于生物体的初始状态。因此，具有初始“典型血液”特征的狗通常具有“抑郁”或“活化”状态的血液，在0.25和0.5 Gy的低剂量下对辐射具有异常高的响应。这一事实对于估计人群长期低剂量照射的后果很重要。已经显示在存活测试中有效的放射防护剂激活了器官中dNTP，DNA和蛋白质的合成。 dNTP合成的强度和dNTP库变为最大的时间决定了保护剂的效率和给药后的照射时间。

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