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首页> 外文期刊>Bioprocess and Biosystems Engineering >Mechanistic simulation of batch acetone-butanol-ethanol (ABE) fermentation with in situ gas stripping using Aspen Plus™
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Mechanistic simulation of batch acetone-butanol-ethanol (ABE) fermentation with in situ gas stripping using Aspen Plus™

机译：使用Aspen Plus™进​​行原位气提的间歇式丙酮-丁醇-乙醇（ABE）发酵的机械模拟

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摘要

Process simulations of batch fermentations with in situ product separation traditionally decouple these interdependent steps by simulating a separate "steady state" continuous fermentation and separation units. In this study, an integrated batch fermentation and separation process was simulated for a model system of acetone-butanol-ethanol (ABE) fermentation with in situ gas stripping, such that the fermentation kinetics are linked in real-time to the gas stripping process. A time-dependent cell growth, substrate utilization, and product production is translated to an Aspen Plus batch reactor. This approach capitalizes on the phase equilibria calculations of Aspen Plus to predict the effect of stripping on the ABE fermentation kinetics. The product profiles of the integrated fermentation and separation are shown to be sensitive to gas flow rate, unlike separate steady state fermentation and separation simulations. This study demonstrates the importance of coupled fermentation and separation simulation approaches for the systematic analyses of unsteady state processes.
机译：传统上，通过原位产物分离进行分批发酵的过程模拟，通过模拟单独的“稳态”连续发酵和分离单元，使这些相互依赖的步骤脱钩。在这项研究中，模拟了采用原位汽提的丙酮-丁醇-乙醇（ABE）发酵模型系统的集成分批发酵和分离过程，从而使发酵动力学实时与气提过程相关联。随时间变化的细胞生长，底物利用率和产物生产被转化为Aspen Plus间歇反应器。该方法利用Aspen Plus的相平衡计算来预测汽提对ABE发酵动力学的影响。与单独的稳态发酵和分离模拟不同，整合的发酵和分离的产物曲线显示出对气体流速敏感。这项研究证明了联合发酵和分离模拟方法对于非稳态过程的系统分析的重要性。

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