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首页> 外文期刊>Bioprocess and Biosystems Engineering >Separation and purification of a-ketoglutarate and pyruvate from the fermentation broth of Yarrowia lipolytica
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Separation and purification of a-ketoglutarate and pyruvate from the fermentation broth of Yarrowia lipolytica

机译：从解脂耶氏酵母的发酵液中分离和纯化α-酮戊二酸和丙酮酸

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摘要

A strategy to achieve the efficient co-production of alpha-ketoglutarate (KGA) and pyruvate (PYR) via Yarrowia lipolytica fermentation was established in our previous work. The next big challenge is to achieve an efficient separation of the two keto acids. A strategy for simultaneously separating and purifying KGA and PYR based on their different boiling points was established, leading to the efficient separation and purification of the two keto acids from the fermentation broth of Y. lipolytica. The purity and yield of KGA/PYR reached 99.3/99.5 and 79.8/80.6%, respectively. Application of the separation method on industrial scale could further decrease the cost of the production of the two keto acids by biotechnological routes.
机译：在我们以前的工作中，建立了一种通过解脂耶氏酵母发酵有效联合生产α-酮戊二酸（KGA）和丙酮酸（PYR）的策略。下一个重大挑战是实现两种酮酸的有效分离。建立了基于KGA和PYR的不同沸点同时分离和纯化的策略，从而从解脂耶氏酵母的发酵液中有效分离和纯化了两种酮酸。 KGA / PYR的纯度和产率分别达到99.3 / 99.5和79.8 / 80.6％。在工业规模上分离方法的应用可以进一步降低通过生物技术路线生产两种酮酸的成本。

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  • 来源
    《Bioprocess and Biosystems Engineering》 |2018年第10期|1519-1527|共9页
  • 作者

    Zeng Weizhu; Xu Sha; Du Guocheng; Liu Song; Zhou Jingwen;

  • 作者单位

    Jiangnan Univ, Sch Biotechnol, Minist Educ, Key Lab Ind Biotechnol, 1800 Lihu Rd, Wuxi 214122, Jiangsu, Peoples R China;

    Jiangnan Univ, Sch Biotechnol, Minist Educ, Key Lab Ind Biotechnol, 1800 Lihu Rd, Wuxi 214122, Jiangsu, Peoples R China;

    Jiangnan Univ, Sch Biotechnol, Minist Educ, Key Lab Ind Biotechnol, 1800 Lihu Rd, Wuxi 214122, Jiangsu, Peoples R China;

    Jiangnan Univ, Sch Biotechnol, Minist Educ, Key Lab Ind Biotechnol, 1800 Lihu Rd, Wuxi 214122, Jiangsu, Peoples R China;

    Jiangnan Univ, Sch Biotechnol, Minist Educ, Key Lab Ind Biotechnol, 1800 Lihu Rd, Wuxi 214122, Jiangsu, Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Keto acids; Yarrowia lipolytica; Ethyl acetate; Extraction; Purification;

    机译：酮酸;解脂耶氏酵母;乙酸乙酯;提取;纯化;

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