Efficient lipase-catalyzed Knoevenagel condensation: utilization of biocatalytic promiscuity for synthesis of benzylidene-indolin-2-ones

Ding Yan; Xiang Xinran; Gu Mengjie; Xu Haoran; Huang He; Hu Yi

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Efficient lipase-catalyzed Knoevenagel condensation: utilization of biocatalytic promiscuity for synthesis of benzylidene-indolin-2-ones

机译：高效的脂肪酶催化的Knoevenagel缩合反应：利用生物催化的杂合度来合成亚苄基-吲哚-2-酮

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Based on the screening of biocatalysts and reaction conditions including solvent, water content, temperature, enzyme loading, and reaction time, lipase from porcine pancreas (PPL) showed the prominent promiscuity for the Knoevenagel condensation between 1,3-dihydroindol-2-one heterocycle and aromatic aldehydes. Under the optimized procedure, both electron-withdrawing and electron-donating substituent of aldehydes substrates could react efficiently, and benzylidene-indolin-2-ones were obtained in excellent yields (75.0-96.6 %).

机译：在筛选生物催化剂和反应条件（包括溶剂，水含量，温度，酶负载和反应时间）后，猪胰腺脂肪酶（PPL）显示出1,3-二氢吲哚-2-one杂环之间的Knoevenagel缩合反应显着。和芳香醛。在优化的工艺条件下，醛类底物的吸电子和供电子取代基均能有效反应，得到了亚苄基-吲哚-2-酮，收率极高（75.0-96.6％）。

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来源
《Bioprocess and Biosystems Engineering》 |2016年第1期|125-131|共7页
作者
Ding Yan; Xiang Xinran; Gu Mengjie; Xu Haoran; Huang He; Hu Yi;
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作者单位

Nanjing Tech Univ, Coll Biotechnol & Pharmaceut Engn, State Key Lab Mat Oriented Chem Engn, Nanjing 210009, Jiangsu, Peoples R China;

Nanjing Tech Univ, Coll Biotechnol & Pharmaceut Engn, State Key Lab Mat Oriented Chem Engn, Nanjing 210009, Jiangsu, Peoples R China;

Nanjing Tech Univ, Coll Biotechnol & Pharmaceut Engn, State Key Lab Mat Oriented Chem Engn, Nanjing 210009, Jiangsu, Peoples R China;

Nanjing Tech Univ, Coll Biotechnol & Pharmaceut Engn, State Key Lab Mat Oriented Chem Engn, Nanjing 210009, Jiangsu, Peoples R China;

Nanjing Tech Univ, Coll Biotechnol & Pharmaceut Engn, State Key Lab Mat Oriented Chem Engn, Nanjing 210009, Jiangsu, Peoples R China;

Nanjing Tech Univ, Coll Biotechnol & Pharmaceut Engn, State Key Lab Mat Oriented Chem Engn, Nanjing 210009, Jiangsu, Peoples R China;

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正文语种 eng
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关键词
Lipase; Benzylidene-indolin-2-one; Aromatic aldehydes; Knoevenagel condensation; Biocatalytic promiscuity;

机译：脂肪酶;亚苄基吲哚-2-酮;芳香醛;Knoevenagel缩合;生物催化混杂;

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Efficient lipase-catalyzed Knoevenagel condensation: utilization of biocatalytic promiscuity for synthesis of benzylidene-indolin-2-ones

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