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首页> 外文期刊>Bioprocess and Biosystems Engineering >A biotransformation process for the production of cucurbitacin B from its glycoside using a selected Streptomyces sp.
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A biotransformation process for the production of cucurbitacin B from its glycoside using a selected Streptomyces sp.

机译：使用选定的链霉菌属菌种从其糖苷生产葫芦素B的生物转化过程。

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摘要

Cucurbitacin B (CuB) and its glycoside, cucurbitacin B 2-O-beta-D-glucoside (CuBg), abundantly occur in the pedicels of Cucumis melo. Compared with CuB, CuBg is not efficiently extracted from the pedicels. Furthermore, the anticancer activity of CuBg is lower than that of the aglycone. A process for CuBg biotransformation to CuB was developed for the first time. A strain of Streptomyces species that converts CuBg into CuB was isolated from an enrichment culture of C. melo pedicels. After optimization of conditions for enzyme production and biotransformation, a maximum conversion rate of 92.6 % was obtained at a CuBg concentration of 0.25 g/L. When biotransformation was performed on C. melo pedicel extracts, the CuB concentration in the extracts increased from 1.50 to 3.27 g/L. The conversion rate was almost 100 %. The developed process may be an effective biotransformation method for industrial production CuB from C. melo pedicels for pharmaceuticals.
机译：葫芦素B（CuB）及其糖苷葫芦素B2-O-β-D-葡糖苷（CuBg）大量存在于黄瓜中。与CuB相比，不能从花梗中有效提取CuBg。此外，CuBg的抗癌活性低于糖苷配基的抗癌活性。首次开发了将CuBg生物转化为CuB的方法。从C. melo花梗的富集培养物中分离出将CuBg转化为CuB的链霉菌属菌株。优化酶生产和生物转化的条件后，CuBg浓度为0.25 g / L时，最大转化率为92.6％。当对C. melo pedicel提取物进行生物转化时，提取物中的CuB浓度从1.50 g / L增加到3.27 g / L。转化率几乎为100％。所开发的方法可能是一种有效的生物转化方法，可用于从药用花梗中工业生产CuB。

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  • 来源
    《Bioprocess and Biosystems Engineering》 |2016年第9期|1435-1440|共6页
  • 作者

    Mei Jianfeng; Li Sha; Jin Hang; Tang Lan; Yi Yu; Wang Hong; Ying Guoqing;

  • 作者单位

    Zhejiang Univ Technol, Coll Pharmaceut Sci, 18 Chaowang Rd, Hangzhou 310032, Zhejiang, Peoples R China;

    Zhejiang Univ Technol, Coll Pharmaceut Sci, 18 Chaowang Rd, Hangzhou 310032, Zhejiang, Peoples R China;

    Zhejiang Univ Technol, Coll Pharmaceut Sci, 18 Chaowang Rd, Hangzhou 310032, Zhejiang, Peoples R China;

    Zhejiang Univ Technol, Coll Pharmaceut Sci, 18 Chaowang Rd, Hangzhou 310032, Zhejiang, Peoples R China;

    Zhejiang Univ Technol, Coll Pharmaceut Sci, 18 Chaowang Rd, Hangzhou 310032, Zhejiang, Peoples R China;

    Zhejiang Univ Technol, Coll Pharmaceut Sci, 18 Chaowang Rd, Hangzhou 310032, Zhejiang, Peoples R China;

    Zhejiang Univ Technol, Coll Pharmaceut Sci, 18 Chaowang Rd, Hangzhou 310032, Zhejiang, Peoples R China;

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  • 正文语种 eng
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  • 关键词

    Cucurbitacin B 2-O-beta-D-glucoside; Cucurbitacin B; Biotransformation; Streptomyces sp;

    机译：葫芦素B2-O-β-D-葡萄糖苷;葫芦素B;生物转化;链霉菌;

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