...
首页> 外文期刊>Bioprocess and Biosystems Engineering >Effects of bioreactor hydrodynamics on the physiology of Streptomyces
【24h】

Effects of bioreactor hydrodynamics on the physiology of Streptomyces

机译:生物反应器流体动力学对链霉菌生理的影响

获取原文
获取原文并翻译 | 示例
           

摘要

Streptomyces are filamentous bacteria which are widely used industrially for the production of therapeutic biomolecules, especially antibiotics. Bioreactor operating conditions may impact the physiological response of Streptomyces especially agitation and aeration as they influence hydromechanical stress, oxygen and nutrient transfer. The understanding of the coupling between physiological response and bioreactor hydrodynamics lies on a simultaneous description of the flow and transfers encountered by the bacteria and of the microbial response in terms of growth, consumption, morphology, production or intracellular signals. This article reviews the experimental and numerical works dedicated to the study of the coupling between bioreactor hydrodynamics and antibiotics producing Streptomyces. In a first part, the description of hydrodynamics used in these works is presented and then the main relations used. In a second part, the assumptions made in these works are discussed and put into emphasize. Lastly, the various Streptomyces physiological responses observed are detailed and compared.
机译:链霉菌是丝状细菌,其在工业上广泛用于生产治疗性生物分子,特别是抗生素。生物反应器的运行条件可能会影响链霉菌的生理反应,尤其是搅动和通气,因为它们会影响液压应力,氧气和养分的转移。对生理反应和生物反应器流体动力学之间耦合的理解在于细菌在生长,消耗,形态,产生或细胞内信号方面同时遇到的流量和转移以及微生物反应的描述。本文回顾了致力于研究生物反应器流体动力学与产生链霉菌的抗生素之间的耦合的实验和数值研究。在第一部分中,介绍了在这些工作中使用的流体动力学的描述,然后介绍了主要的关系。在第二部分中,讨论并强调了在这些工作中所做的假设。最后,对观察到的各种链霉菌的生理反应进行了详细的比较。

著录项

  • 来源
    《Bioprocess and Biosystems Engineering》 |2013年第3期|259-272|共14页
  • 作者单位

    CNRS, 54505 Vandoeuvre-les-Nancy, France,CNRS, Universite de Lorraine, 54505 Vandoeuvre-les-Nancy,France;

    CNRS, 54505 Vandoeuvre-les-Nancy, France,CNRS, Universite de Lorraine, 54505 Vandoeuvre-les-Nancy,France;

    CNRS, 54505 Vandoeuvre-les-Nancy, France,CNRS, Universite de Lorraine, 54505 Vandoeuvre-les-Nancy,France;

    CNRS, 54505 Vandoeuvre-les-Nancy, France,CNRS, Universite de Lorraine, 54505 Vandoeuvre-les-Nancy,France;

    CNRS, 54505 Vandoeuvre-les-Nancy, France,CNRS, Universite de Lorraine, 54505 Vandoeuvre-les-Nancy,France;

    CNRS, 54505 Vandoeuvre-les-Nancy, France,CNRS, Universite de Lorraine, 54505 Vandoeuvre-les-Nancy,France;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    bioreactor; hydrodynamics; streptomyces; mass transfer; antibiotic production;

    机译:生物反应器流体力学链霉菌传质抗生素生产;

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号