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首页> 外文期刊>Bioprocess and Biosystems Engineering >Enzymatic synthesis of poly-L-lactide and poly-L-lactide-co-glycolide in an ionic liquid
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Enzymatic synthesis of poly-L-lactide and poly-L-lactide-co-glycolide in an ionic liquid

机译：离子液体中酶法合成聚-L-丙交酯和聚-L-丙交酯-乙交酯

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摘要

The syntheses of poly-L-lactide (PLLA) and poly-L-lactide-co-glycolide (PLLGA) is reported in the ionic liquid 1-hexyl-3-methylimidazolium hexafluoro-phosphate [HMIM][PF_6] mediated by the enzyme lipase B from Candida antarctica (Novozyme 435). The highest PLLA yield (63%) was attained at 90 ℃ with a molecular weight (M_n) of 37.8 × 10~3 g/mol determined by size exclusion chromatography. This procedure produced relatively high crystalline polymers (up to 85% PLLA) as determined by DSC. In experiments at 90 ℃ product synthesis also occurred without biocatalyst, however, PLLA synthesis in [HMIM][PF_6] at 65 ℃ followed only the enzymatic mechanism as ring opening was not observed without the enzyme. In addition, the enzymatic synthesis of PLLGA is first reported here using Novozyme 435 biocatalyst with up to 19% of lactyl units in the resulting copolymer as determined by NMR. Materials were also characterized by TGA, MALDI-TOF-MS, X-ray diffraction, polarimetry and rheology.
机译：该酶介导的离子液体1-己基-3-甲基咪唑鎓六氟磷酸盐[HMIM] [PF_6]中报道了聚-L-丙交酯（PLLA）和聚-L-丙交酯-乙交酯（PLLGA）的合成来自南极假丝酵母的脂肪酶B（Novozyme 435）。 90℃时PLLA的收率最高（63％），分子量排阻色谱法测定的分子量（M_n）为37.8×10〜3 g / mol。通过DSC测定，该方法产生了相对较高的结晶聚合物（高达85％的PLLA）。在90℃的实验中，也没有生物催化剂也发生了产物合成，但是[65]在[HMIM] [PF_6]中的PLLA合成遵循酶的机制，因为没有酶就没有观察到开环。另外，这里首先报道了通过Novozyme 435生物催化剂进行的PLLGA的酶促合成，通过NMR测定，所得到的共聚物中具有高达19％的乳酰基单元。还通过TGA，MALDI-TOF-MS，X射线衍射，旋光法和流变学对材料进行了表征。

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  • 来源
    《Bioprocess and Biosystems Engineering》 |2010年第5期|P.629-638|共10页
  • 作者

    Sebastien Chanfreau; rnMaria Mena; rnJaime R. Porras-Dominguez; Mariana Ramirez-Gilly; rnMiquel Gimeno; rnPedro Roquero; Alberto Tecante; rnEduardo Barzana;

  • 作者单位

    Departamento de Alimentos y Biotecnologia, Facultad de Quimica, Universidad Nacional Autonoma de Mexico, Ciudad Universitaria, 04510 Mexico, DF, Mexico Departamento de Ingenieria Quimica, Facultad de Quimica, Universidad Nacional Autonoma de Mexico, Ciudad Universitaria, 04510 Mexico, DF, Mexico;

    rnDepartamento de Alimentos y Biotecnologia, Facultad de Quimica, Universidad Nacional Autonoma de Mexico, Ciudad Universitaria, 04510 Mexico, DF, Mexico;

    rnDepartamento de Alimentos y Biotecnologia, Facultad de Quimica, Universidad Nacional Autonoma de Mexico, Ciudad Universitaria, 04510 Mexico, DF, Mexico;

    rnDepartamento de Alimentos y Biotecnologia, Facultad de Quimica, Universidad Nacional Autonoma de Mexico, Ciudad Universitaria, 04510 Mexico, DF, Mexico;

    rnDepartamento de Alimentos y Biotecnologia, Facultad de Quimica, Universidad Nacional Autonoma de Mexico, Ciudad Universitaria, 04510 Mexico, DF, Mexico;

    rnDepartamento de Ingenieria Quimica, Facultad de Quimica, Universidad Nacional Autonoma de Mexico, Ciudad Universitaria, 04510 Mexico, DF, Mexico;

    rnDepartamento de Alimentos y Biotecnologia, Facultad de Quimica, Universidad Nacional Autonoma de Mexico, Ciudad Universitaria, 04510 Mexico, DF, Mexico;

    rnDepartamento de Alimentos y Biotecnologia, Facultad de Quimica, Universidad Nacional Autonoma de Mexico, Ciudad Universitaria, 04510 Mexico, DF, Mexico;

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  • 正文语种 eng
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  • 关键词

    poly-L-lactide; poly-L-lactide-co-glycolide ionic liquids; novozyme 435; ring-opening polymerization; rheology;

    机译：聚-L-丙交酯;聚-L-丙交酯-乙交酯离子液体;新酶435;开环聚合;流变学;

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