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Modelling and optimisation of enzymatic separating micro-reactor

机译：酶分离微反应器的建模与优化

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A mathematical model of an enzymatic separating microreactor with the electro-osmotic control of reaction component transport rates is analysed. The micro-reactor is considered in a form of a thin channel filled with a gel containing an immobilised enzyme and an adsorbent where the enzyme reaction, the molecular diffusion, the electro-osmotic flux and the adsorption take place. The substrate inhibited enzyme reaction splitting a non-ionic substrate to two non-ionic products is considered. The reactor operates in a periodic regime, when the channel entry is exposed to the periodic substrate concentration pulses. A chromatographic separation of reaction components, therefore, proceeds in the channel. Effects of principal operational parameters of the reactor system-the reaction channel length, the electric current density, the substrate inlet concentration, the rate of adsorption, and the enzyme activity-on resolution of the products at reactor outlet are analysed. The existence of optimum parameter values (maximising the resolution of reaction products) is shown and a multiparametric optimisation of the reactor performance is accomplished.
机译：分析了酶分离微反应器的电渗控制反应组分传输速率的数学模型。认为微反应器是填充有包含固定化酶和吸附剂的凝胶的细通道的形式，其中发生酶反应，分子扩散，电渗通量和吸附。考虑了底物抑制的酶反应，该反应将非离子底物分裂为两种非离子产物。当通道入口暴露于周期性的底物浓度脉冲时，反应器以周期性的方式运行。因此，反应成分的色谱分离在通道中进行。分析了反应器系统的主要操作参数-反应通道长度，电流密度，底物入口浓度，吸附速率和酶活度-对反应器出口产物分离度的影响。显示了最佳参数值的存在（最大程度地提高了反应产物的分离度），并实现了反应器性能的多参数优化。

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