...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Bioprocess and Biosystems Engineering >Average shear rate in airlift bioreactors: searching for the true value
【24h】

Average shear rate in airlift bioreactors: searching for the true value

机译：空运生物反应器中的平均剪切速率：寻找真实值

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The shear rate is an important bioreactor parameter that needs to be evaluated due to its impact on microorganism morphology and viability, and consequently on bioproduct formation. Airlift bioreactors, classified as low-shear devices, are used as an alternative to conventional stirred-tank reactors. Considerable efforts have been made to characterize the shear environments in airlift bioreactors, using the average shear rate as a key parameter. However, there is no agreement among the values obtained in different studies, which can differ even in orders of magnitude. The methodologies used to obtain av in the different studies could be the reason for the lack of agreement among them. In this work, av in a concentric tube airlift bioreactor was evaluated using computational fluid dynamics (CFD), as well as based on universal velocity profiles for liquid flows in smooth pipes and annuli. Good agreement was obtained between the CFD-based average shear rates and the values obtained from universal velocity profiles, indicating that CFD simulation is a valuable tool for av prediction.
机译：剪切速率是重要的生物反应器参数，由于其对微生物形态和生存力以及因此对生物产物形成的影响，需要对其进行评估。划为低剪切装置的空运生物反应器被用作常规搅拌釜反应器的替代品。使用平均剪切速率作为关键参数，已经做出了大量努力来表征气举生物反应器中的剪切环境。但是，在不同研究中获得的值之间并没有一致，甚至在数量级上也可能不同。在不同的研究中用于获得av的方法可能是它们之间缺乏一致性的原因。在这项工作中，使用计算流体动力学（CFD）以及基于光滑管和环空中液体流动的通用速度曲线，对同心管空运生物反应器中的av进行了评估。在基于CFD的平均剪切速率和从通用速度剖面获得的值之间获得了很好的一致性，表明CFD模拟是进行AV预测的有价值的工具。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号