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首页> 外文期刊>Bioprocess and Biosystems Engineering >Influence of the construction of porous spargers on lovastatin production by Aspergillus terreus ATCC 20,542 in a laboratory bubble column
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Influence of the construction of porous spargers on lovastatin production by Aspergillus terreus ATCC 20,542 in a laboratory bubble column

机译：多孔辐射器在实验室泡沫柱中曲霉菌血管菌菌达苜蓿生产的影响

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摘要

In bubble column bioreactors, the hydrodynamic behavior like mixing time, bubble size and morphology of filamentous fungi are influenced by the construction of spargers. Sparger pore size is an important factor influencing formation of bubbles. In this study for the first time, a 5-L bubble column bioreactor with different porous spargers was used to investigate the effect of mean air bubble diameter (at 0.36, 0.18 and 0.09cm) on fungal growth, broth viscosity, fungal pellet morphology and lovastatin production by the filamentous fungus Aspergillus terreus. All cultivations were carried out at air flow rate equal to 0.5 L-air L(-1)min(-1). The viscosity of the broth was influenced by both biomass concentration and size of the fungal pellets. The highest values of viscosity were observed at bubbles of 0.09cm diameter after 192h of cultivation. The largest fluffy pellets and the highest yield of lovastatin (443mg/L) were obtained at air bubbles diameter of 0.18cm. Lovastatin yield on biomass growth in this condition was, respectively, 1.7-fold and 3.5-fold higher than in the cultivations performed with air bubbles of 0.36 and 0.09cm diameters. These laboratory scale experiment indicates that air bubble diameter has the impact on lovastatin production and A. terreus culture conditions.
机译：在气泡柱生物反应器中，丝状真菌的混合时间，泡沫尺寸和形态等流体动力学行为受练习刀的构建影响。 Sparger孔径是影响泡沫形成的重要因素。在本研究首次，使用具有不同多孔辐射器的5-L气泡柱生物反应器来研究平均气泡直径（0.36,0.18和0.09cm）对真菌生长，肉汤粘度，真菌颗粒形态和Lovastatin由丝状真菌aspergillus terreus产生。所有培养在空气流速等于0.5升 - 空气L（-1）min（-1）时进行。肉汤的粘度受到真菌粒料的生物质浓度和大小的影响。在培养192小时后，在0.09cm的气泡下观察到粘度的最高值。在气泡直径为0.18cm的气泡中获得最大的蓬松粒料和洛伐他汀（443mg / L）的最高产率。洛伐他汀在这种情况下的生物质生长产量分别为1.7倍和3.5倍，比在0.36和0.09cm直径为0.36和0.09cm的气泡中进行的培养。这些实验室规模实验表明气泡直径对洛伐他汀生产的影响和A.Terreus培养条件。

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