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首页> 外文期刊>Bioprocess and Biosystems Engineering >Bioengineered gold nanoparticles from marine seaweed Acanthophora spicifera for pharmaceutical uses: antioxidant, antibacterial, and anticancer activities
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Bioengineered gold nanoparticles from marine seaweed Acanthophora spicifera for pharmaceutical uses: antioxidant, antibacterial, and anticancer activities

机译:来自海洋海藻刺激素Spicifera的生物工程金纳米粒子用于药物用途:抗氧化剂,抗菌和抗癌活动

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摘要

In this study, we report a green synthesis of pharmaceutically active gold nanoparticles from marine red algaAcanthophora spiciferaby the reduction of chloroauric acid. The formation ofA. spicifera-mediated gold nanoparticles (As-AuNPs) was characterized by several analytical techniques. The crystalline and face-centered cubic (fcc) structure were confirmed by X-ray diffraction (XRD) analysis. Electron microscopy results confirmed that As-AuNPs were spherical and the average size of particles was 20 nm. As-AuNPs hold a significant level of antioxidant activities thanA. spiciferaextract. As-AuNPs exhibited the highest antibacterial activity againstVibrio harveyithanStaphylococcus aureusat 100 mu g/ml. Furthermore, As-AuNPs exhibited the utmost cytotoxicity against human colon adenocarcinoma (HT-29) cells and registered the half-maximal inhibitory concentration (IC50) at 21.86 mu g/ml. These findings authenticated that the synthesized As-AuNPs possess a broad spectrum of biological activities, and it can be effectively applied in the field of aquaculture and biomedical application.
机译:在这项研究中,我们报告了来自海洋红藻藻生物植物Spififeraby的药物活性金纳米粒子的绿色合成,减少了氯娃氏酸的还原。形成的。 Spififera介导的金纳米颗粒(AS-AUNPS)的特征在于几种分析技术。通过X射线衍射(XRD)分析证实了结晶和面为中心的立方(FCC)结构。电子显微镜结果证实,AS-AUNPS是球形的,颗粒的平均尺寸<20nm。 AS-AUNPS持有显着的抗氧化活性。 spiciferaextract。 AS-AUNPS表现出最高的抗菌活性抗菌活性,抗菌活性AUFRUSAT100μg/ ml。此外,AS-AUNPS表现出对人结肠腺癌(HT-29)细胞的最大细胞毒性,并在21.86μg/ mL下登记半最大抑制浓度(IC 50)。这些调查结果认证,合成的AS-AUNP具有广泛的生物活性,可以有效地应用于水产养殖和生物医学应用领域。

著录项

  • 来源
    《Bioprocess and Biosystems Engineering》 |2020年第12期|2231-2242|共12页
  • 作者单位

    Alagappa Univ Dept Anim Hlth & Management Dis Control & Prevent Lab Karaikkudi 630003 Tamil Nadu India;

    Gangneung Wonju Natl Univ East Coast Life Sci Inst 120 Gangneung Gangwon 210720 South Korea|Gangneung Wonju Natl Univ Dept Marine Food Sci & Technol 120 Gangneungdaehangno Kangnung 210702 Gangwon South Korea;

    Alagappa Univ Dept Anim Hlth & Management Dis Control & Prevent Lab Karaikkudi 630003 Tamil Nadu India;

    Alagappa Univ Dept Anim Hlth & Management Dis Control & Prevent Lab Karaikkudi 630003 Tamil Nadu India;

    Alagappa Univ Dept Anim Hlth & Management Food Chem & Mol Canc Biol Lab Karaikkudi 630003 Tamil Nadu India;

    Alagappa Univ Dept Bioinformat Karaikkudi 630003 Tamil Nadu India;

    Tarbiat Modares Univ Fac Marine Sci Dept Seafood Proc POB 46414-356 Noor Iran;

    Gangneung Wonju Natl Univ East Coast Life Sci Inst 120 Gangneung Gangwon 210720 South Korea|Gangneung Wonju Natl Univ Dept Marine Food Sci & Technol 120 Gangneungdaehangno Kangnung 210702 Gangwon South Korea;

    Alagappa Univ Dept Anim Hlth & Management Dis Control & Prevent Lab Karaikkudi 630003 Tamil Nadu India;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Marine algae; Gold nanoparticles; Antioxidant; Antibacterial; Cytotoxic activity;

    机译:海藻;金纳米颗粒;抗氧化剂;抗菌;细胞毒性活性;

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