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首页> 外文期刊>Brain and cognition >Transcranial direct current stimulation over the right and left VLPFC leads to differential effects on working and episodic memory
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Transcranial direct current stimulation over the right and left VLPFC leads to differential effects on working and episodic memory

机译：左右VLPFC的经颅直流电刺激导致对工作记忆和情景记忆的不同影响

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摘要

Previous research suggests that the left VLPFC is involved in working memory, whereas right VLPFC is involved with subsequent episodic memory. High-Definition Transcranial Direct Current Stimulation (HD-tDCS) was used to test whether excitation of the left or right VLPFC would show differential effects of negative and neutral stimuli on working memory and episodic memory tasks. While receiving HD-tDCS over the left or right VLPFC or sham stimulation, participants completed a working memory task with negative and neutral distractors followed by a surprise recognition test for the distractors. HD-tDCS over the left VLPFC led to improved working memory performance compared to sham for both negative and neutral distractors. However, for trials that were subsequently remembered, a greater proportion of working memory trials were correct for both the right and left VLPFC group compared to the sham group, for both negative and neutral distractors. Whereas the results from the left VLPFC group can be attributed to overall higher working memory performance, findings from the right VLPFC suggest a role of the right VLPFC in coping with distracting stimuli. Taken together, these results indicate causal roles for the left VLPFC in working memory and the right VLPFC in working memory and episodic memory.
机译：先前的研究表明，左VLPFC与工作记忆有关，而右VLPFC与后续的情节记忆有关。高清晰度经颅直流电刺激（HD-tDCS）用于测试左侧或右侧VLPFC的激励是否会显示负刺激和中性刺激对工作记忆和间歇性记忆任务的不同影响。在通过左VLPFC或右VLPFC或假刺激接收HD-tDCS时，参与者完成了带有消极和中性干扰物的工作记忆任务，随后进行了针对干扰物的突击识别测试。与假阴性和中性干扰物相比，左VLPFC上的HD-tDCS改善了工作记忆性能。但是，对于随后被记住的试验，无论是阴性还是中性干扰物，与假手术组相比，左右VLPFC组的工作记忆试验正确率更高。左VLPFC组的结果可以归因于总体上更高的工作记忆性能，而右VLPFC的发现表明右VLPFC在应对分散注意力刺激方面的作用。综上，这些结果表明左VLPFC在工作记忆中以及右VLPFC在工作记忆和情节性记忆中起因果作用。

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