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Clinicopathological features in the recurrence of oligodendroglioma and diffuse astrocytoma

机译：少突胶质细胞瘤和弥漫性星形细胞瘤复发的临床病理特征

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To investigate whether grade II oligodendroglioma was transformed to glioblastoma or not, histopathological evaluation of recurrent oligodendrogliomal tumors (OG) and diffuse astrocytomas (DA) was performed. The OG group was composed of ten patients with OG, including seven oligodendrogliomas and three oligoastrocytomas. The DA group was composed of ten patients with DA, including eight fibrillary astrocytomas and two gemistocytic astrocytomas. The histopathological parameters of glioblastoma including nuclear atypia, multinucleated giant cells, glomeruloid tufts (GT) as a marker of microvascular proliferation, necrosis, and the Ki-67 staining index were investigated. Evaluation of these parameters was scored as follows: 0, none; 1, sporadic; 2, partial; 3, extensive. There were no cases of transformation to glioblastoma in the OG group. There were five cases of transformation to secondary glioblastoma in the DA group. In recurrent tumors, scores of GT and necrosis in the OG group were significantly lower than those in the DA group (p < 0.005). Nuclear atypia and high proliferative activity (Ki-67 index) were identified in recurrent tumors of the OG group. Our study suggested that the extent of GT and necrosis in recurrent OG was less than that in recurrent DA, and transformation to glioblastoma from oligodendroglial tumor was exceptional.
机译：为了研究II级少突胶质细胞瘤是否转化为胶质母细胞瘤，对复发性少突胶质细胞瘤（OG）和弥漫性星形细胞瘤（DA）进行了组织病理学评估。 OG组由10例OG患者组成，其中包括7例少突胶质细胞瘤和3例少突胶质细胞瘤。 DA组由10例DA患者组成，其中包括8个原纤维星形细胞瘤和2个双核星形细胞瘤。研究了胶质母细胞瘤的组织病理学参数，包括核非典型性，多核巨细胞，肾小球簇（GT）作为微血管增殖，坏死的标志物以及Ki-67染色指数。对这些参数的评估得分如下：0，无； 1，零星的； 2，偏； 3，广泛。 OG组中没有转化为胶质母细胞瘤的病例。 DA组中有5例转化为继发性胶质母细胞瘤。在复发性肿瘤中，OG组的GT和坏死评分显着低于DA组（p <0.005）。在OG组的复发性肿瘤中发现了核非典型性和高增殖活性（Ki-67指数）。我们的研究表明，复发性OG的GT和坏死程度小于复发性DA，而且少突胶质细胞瘤向胶质母细胞瘤的转化非常出色。

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