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首页> 外文期刊>Brain Tumor Pathology >A case of cerebral ganglioneuronal tumor in the parietal lobe of an adult
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A case of cerebral ganglioneuronal tumor in the parietal lobe of an adult

机译：成人顶叶脑神经节神经瘤一例

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摘要

Central nervous system (CNS) neuroblastoma/ganglioneuroblastoma is one of the embryonal tumors with neuronal differentiation found in young adults, but it is most common in children, especially in those below the age of 5 years, whereas extraventricular neurocytoma, a rare neuroepithelial tumor with neuronal differentiation, mostly affects young adults. Here we present a rare case of cerebral ganglioneuronal tumor that occurred in a 32-year-old woman. The patient suffered from tonic convulsion, and computed tomography demonstrated a well-demarcated, round tumor 3.3 cm in size with marked calcification in the right parietal lobe. Histological analysis revealed diffuse infiltration of small, round cells with scattered large ganglion-like cells. Immunohistochemically, the tumor cells did not react with any neuronal molecules, except for chromogranin A in ganglion-like large tumor cells, but electron microscopy demonstrated the presence of synapse-like nerve terminal structures without mature postsynaptic density, suggesting the presence of neoplastic tumor components with neuronal differentiation; thus, this tumor was diagnosed as CNS ganglioneuroblastoma with possible low-grade malignancy because the Mib-1 labeling index was less than 3%–4%. Here we discuss the histological entity of cerebral ganglioneuronal tumors, including extraventricular neurocytoma.
机译：中枢神经系统（NSS）神经母细胞瘤/神经节神经母细胞瘤是在年轻人中发现的具有神经元分化的胚胎肿瘤之一，但最常见于儿童，尤其是5岁以下的儿童，而脑室外神经细胞瘤是一种罕见的神经上皮瘤神经元分化，主要影响年轻人。在这里，我们介绍了在32岁的女性中发生的罕见神经节神经节肿瘤病例。该患者患有强直性惊厥，计算机断层扫描显示右侧边界壁上有明显划定的圆形肿瘤，大小为3.3 cm，钙化明显。组织学分析显示，小圆形细胞弥漫性浸润，散布有大神经节样细胞。免疫组织化学分析，除了神经节样大肿瘤细胞中的嗜铬粒蛋白A以外，肿瘤细胞不与任何神经元分子反应，但电子显微镜显示突触样神经末梢结构的存在而没有成熟的突触后密度，表明存在肿瘤性肿瘤成分神经元分化因此，由于Mib-1标记指数低于3％–4％，因此该肿瘤被诊断为中枢神经系统神经节神经母细胞瘤，可能具有低度恶性肿瘤。在这里，我们讨论了脑神经节神经瘤肿瘤的组织学实体，包括室外神经细胞瘤。

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  • 来源
    《Brain Tumor Pathology》 |2008年第1期|45-49|共5页
  • 作者

    Hiroshi Nishihara; Yoshimaru Ozaki; Tamio Ito; Tomoaki Yoshinaga; Kouichi Tabu; Mishie Tanino; Kazuo Nagashima; Shinya Tanaka;

  • 作者单位

    Department of Molecular and Cellular Pathology Hokkaido University Graduate School of Medicine N15W7 Kitaku Sapporo 060-8638 Japan;

    Department of Neurosurgery Nakamura Memorial Hospital Sapporo Japan;

    Department of Neurosurgery Nakamura Memorial Hospital Sapporo Japan;

    Department of Molecular and Cellular Pathology Hokkaido University Graduate School of Medicine N15W7 Kitaku Sapporo 060-8638 Japan;

    Department of Molecular and Cellular Pathology Hokkaido University Graduate School of Medicine N15W7 Kitaku Sapporo 060-8638 Japan;

    Department of Molecular and Cellular Pathology Hokkaido University Graduate School of Medicine N15W7 Kitaku Sapporo 060-8638 Japan;

    Department of Pathology Sapporo-Higashi Tokushuukai Hospital Sapporo Japan;

    Department of Molecular and Cellular Pathology Hokkaido University Graduate School of Medicine N15W7 Kitaku Sapporo 060-8638 Japan;

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  • 正文语种 eng
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  • 关键词

    Ganglioneuroblastoma; Extraventricular neurocytoma; Immunohistochemistry; Electron microscope;

    机译：神经节神经母细胞瘤;脑室外神经细胞瘤;免疫组织化学;电子显微镜;

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