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Infiltrating Lobular Carcinoma of the Breast: Systemic Treatment

机译：浸润性乳腺小叶癌：全身治疗

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摘要

Invasive lobular carcinoma (ILC) is the second most common type of breast cancer after invasive ductal carcinoma (IDC). It is characterized by unique clinical, biological and molecular properties. ILC is almost always positive for the estrogen receptor and is typically of a lower grade compared with IDC. We have reviewed selected literature on preoperative (neoadjuvant) and adjuvant systemic therapy of breast cancer focusing on the differential therapy of ILC. Despite the importance of this type of breast cancer, information about its specific treatment is sparse, in particular with regard to adjuvant systemic chemotherapy. ILC has significantly lower rates of response to neoadjuvant chemotherapy compared with IDC; however, the low chemosensitivity seems not to result in a survival disadvantage. Adjuvant hormonal therapy studies do not distinguish between ILC and IDC. Thus, recommendations about endocrine therapies are made using the same criteria as for IDC.
机译：侵袭性小叶癌（ILC）是继侵袭性导管癌（IDC）之后第二大最常见的乳腺癌类型。它具有独特的临床，生物学和分子特性。 ILC几乎总是对雌激素受体呈阳性，并且与IDC相比通常等级较低。我们回顾了有关乳腺癌的术前（新辅助）和辅助全身治疗的精选文献，重点是ILC的差异治疗。尽管这类乳腺癌非常重要，但有关其具体治疗的信息仍然很少，特别是在辅助全身化疗方面。与IDC相比，ILC对新辅助化疗的反应率明显较低；然而，低化学敏感性似乎不会导致生存不利。激素辅助治疗研究没有区分ILC和IDC。因此，使用与IDC相同的标准提出有关内分泌治疗的建议。

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  • 来源
    《Breast Disease》 |2009年第1期|45-52|共8页
  • 作者

    Simone Anna Farese; Stefan Aebi;

  • 作者单位

    Division of Medical Oncology and Breast/Gynaecologic Cancer Center, Berne University Hospital, and Swiss Group of Clinical Cancer Research (SAKK), Berne, Switzerland;

    Division of Medical Oncology and Breast/Gynaecologic Cancer Center, Berne University Hospital, and Swiss Group of Clinical Cancer Research (SAKK), Berne, Switzerland;

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