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首页> 外文期刊>British Journal of Nutrition >Influence of a combination of Lactobacillus acidophilus NCFM and lactitol on healthy elderly: intestinal and immune parameters
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Influence of a combination of Lactobacillus acidophilus NCFM and lactitol on healthy elderly: intestinal and immune parameters

机译：嗜酸乳杆菌NCFM和乳糖醇联合使用对健康老年人的影响：肠道和免疫指标

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With increasing age, a number of physiological changes take place which are reflected in immune and bowel function. These changes may relatento the commonly assumed age-related changes in intestinal microbiota; most noticeably a reduction in bifidobacteria. The current study aimednat modifying the intestinal microbiota with a potential synbiotic on selected immune and microbiota markers. Healthy elderly subjects werenrandomised to consume during 2 weeks either a placebo (sucrose) or a combination of lactitol and Lactobacillus acidophilus NCFM twicendaily in a double-blind parallel trial. After the intervention, stool frequency was higher in the synbiotic group than in the placebo group and ansignificant increase in faecal L. acidophilus NCFM levels was observed in the synbiotic group, after baseline correction. In contrast to the generallynheld opinion, the study subjects had faecal Bifidobacterium levels that were similar to those reported in healthy young adults. These levels were,nnevertheless, significantly increased by the intervention. Levels of SCFA were not changed significantly. Of the measured immune markers, PGE2nlevels were different between treatments and IgA levels changed over time. These changes were modest which may relate to the fact thatnthe volunteers were healthy. Spermidine levels changed over time which may suggest an improved mucosal integrity and intestinal motility.nThe results suggest that consumption of lactitol combined with L. acidophilus NCFM twice daily may improve some markers of the intestinalnmicrobiota composition and mucosal functions.
机译：随着年龄的增长，许多生理变化发生在免疫和肠功能上。这些变化可能与通常认为的肠道菌群的年龄相关变化有关。最明显的是双歧杆菌的减少。目前的研究旨在通过对选定的免疫和微生物标记物进行潜在的合生来修饰肠道微生物。在一项双盲平行试验中，健康的老年受试者被随机分配在两周内服用安慰剂（蔗糖）或乳糖醇和嗜酸乳杆菌NCFM的组合，每天服用两次。干预后，合生素组的粪便频率高于安慰剂组，基线校正后，合生素组观察到粪便嗜酸乳杆菌NCFM水平显​​着增加。与普遍认为相反，研究对象的粪便双歧杆菌水平与健康的年轻人相似。但是，这些水平由于干预而显着增加。 SCFA的水平没有显着变化。在所测量的免疫标记中，不同治疗之间的PGE2n水平不同，并且IgA水平随时间而变化。这些变化是适度的，这可能与志愿者健康的事实有关。亚精胺水平随时间而变化，这可能表明粘膜完整性和肠蠕动得到改善。n结果表明，每天两次食用乳糖醇与嗜酸乳杆菌NCFM结合可以改善一些肠道菌群组成和粘膜功能的标志物。

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