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首页> 外文期刊>British journal of oral & maxillofacial surgery >Antibiotic prophylaxis for orthognathic surgery: a prospective, randomised clinical trial.
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Antibiotic prophylaxis for orthognathic surgery: a prospective, randomised clinical trial.

机译：正颌外科手术的抗生素预防：一项前瞻性随机临床试验。

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A prospective, randomised, placebo-controlled double-blind clinical trial, compared short-term (1 day) and long-term (5 days) antibiotic prophylaxis after orthognathic surgery. Thirty four patients had single jaw or bimaxillary osteotomies and were given two perioperative doses of amoxycillin. Patients were then randomised to receive either placebo or amoxycillin for 5 days in a double-blind manner. Postoperatively the patients were monitored for infection by scoring a series of validated measurements of infection. In the postoperative period four patients required additional antibiotics in the short-term group and two in the long-term group (P = 0.67). Morbidity scores were higher in the short-term group, at 406 to 264 (P = 0.04), and when individual variables were compared there was a significant difference in the degree of swelling (P = 0.04). Although a 5-day regimen of antibiotic prophylaxis in orthognathic surgery did not decrease the incidence of postoperative infection significantly, it may decrease the morbidity of the operation.
机译：一项前瞻性，随机，安慰剂对照的双盲临床试验，比较了正颌手术后短期（1天）和长期（5天）的抗生素预防措施。 34例患者进行了单颌或双颌截骨术，并接受了两次围术期阿莫西林治疗。然后将患者以双盲方式随机接受安慰剂或阿莫西林治疗5天。手术后，通过对一系列有效的感染测量评分，监测患者的感染情况。在术后阶段，短期组中有4例患者需要额外的抗生素，长期组中有2例患者需要额外的抗生素（P = 0.67）。短期组的发病率评分较高，在406至264之间（P = 0.04），并且在比较各个变量时，肿胀程度存在显着差异（P = 0.04）。尽管在正颌外科手术中采用5天的抗生素预防方案并不能显着降低术后感染的发生率，但可以降低手术的发病率。

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